Allergic fungal sinusitis is the most common form of fungal sinusitis and is common in warm and humid climates. On imaging, it usually presents as opacification and expansion of multiple paranasal sinuses, unilaterally or bilaterally, with content that is centrally hyperdense on CT. MRI shows T2 hypointensity centrally due to the dense fungal concretions and heavy metals.
Allergic fungal sinusitis accounts for 5-10% of chronic hypertrophic sinus disease going to surgery. It is seen in young immunocompetent patients (mean age range 23-42 years). In children, M:F ratio = 2:1 and in adults, M:F ratio = 1:1.4.
- asthma in 65% of cases
Patients may present with chronic headaches, nasal congestion, chronic sinusitis for years, and past sinus surgery.
Allergic fungal sinusitis is an allergic reaction to aerosolized environmental fungi (type 1, IgE-mediated hypersensitivity reaction). Expansion, and even erosion (20%), of the sinuses is characteristic.
Commonly implicated fungi are 1:
- dematiaceous (pigmented) fungi: Bipolaris, Curvularia, Alternaria
- hyaline molds: Aspergillus, Fusarium
Allergic fungal sinusitis usually involves multiple sinuses and can be unilateral or bilateral (the latter is commoner). There is a frequently a nasal component. The ethmoid sinus is the most common location, followed by the maxillary, frontal, and sphenoid sinuses.
The majority of sinuses show near complete opacification. On unenhanced CT, the sinuses are typically opacified by centrally (often serpiginous 7) hyperdense material with a peripheral rim of hypodense mucosa.
Approximately 40% of patients may have each of the following features 4:
- expansion of an involved sinus
- remodeling and thinning of the bone sinus walls
- erosion of the sinus wall
Hypointensity on T1WI and T2WI is the most common finding.
- T1: hypointense inflamed mucosal thickness. It can have multiple T1 appearances.
T1 C+ (Gd):
- an inflamed mucosal lining has contrast enhancement
- no enhancement in the center or in the majority of the sinus contents (cf. neoplasms)
Treatment and prognosis
Allergic fungal sinusitis is usually treated by local excision and steroid therapy. Antifungal therapy is also attempted in some cases, but results of this treatment are equivocal. Recurrence after surgery is not uncommon; however, the inclusion of steroid therapy significantly reduces relapse.
- sinonasal polyposis
sinus fungal mycetoma
- it represents a fungal colonization without hyperimmune response
- usually involving only the maxillary sinus
- it has the same chronic expansive features
- no bone erosions
- sinonasal mass homogeneously hyperdense on non-contrast CT
- 1. Aribandi M, Mccoy VA, Bazan C. Imaging features of invasive and noninvasive fungal sinusitis: a review. Radiographics. 27 (5): 1283-96. doi:10.1148/rg.275065189 - Pubmed citation
- 2. Al-dousary SH. Allergic fungal sinusitis: radiological and microbiological features of 59 cases. Ann Saudi Med. 28 (1): 17-21. - Pubmed citation
- 3. Harnsberger HR. Diagnostic imaging, Head and neck. Amirsys Inc. (2004) ISBN:0721628907. Read it at Google Books - Find it at Amazon
- 4. Mukherji SK, Figueroa RE, Ginsberg LE et-al. Allergic fungal sinusitis: CT findings. Radiology. 1998;207 (2): 417-22. Radiology (citation) - Pubmed citation
- 5. Hicks DL, Dacosta EM, Kearns DB. Radiology quiz case 4. Allergic fungal sinusitis (AFS) of the right sphenoidal sinus. Arch. Otolaryngol. Head Neck Surg. 2004;130 (9): 1123, 1126-7. doi:10.1001/archotol.130.9.1123 - Pubmed citation
- 6. Aribandi M, Bazan C. CT and MRI features in Bipolaris fungal sinusitis. Australas Radiol. 2007;51 (2): 127-32. doi:10.1111/j.1440-1673.2007.01680.x - Pubmed citation
- 7. Bent JP, Kuhn FA. Diagnosis of allergic fungal sinusitis. Otolaryngol Head Neck Surg. 1994;111 (5): 580-8. - Pubmed citation
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