Alpha fetoprotein

Dr Daniel J Bell et al.

Alpha fetoprotein (AFP) is an important plasma protein synthesised by the yolk sac and fetal liver. In adults its main utility is as a tumour marker, primarily for hepatocellular carcinoma or teratoma. Functionally it is the fetal homologue of albumin, i.e. it acts as a major carrier protein in the antenatal circulation. It is encoded for by the AFP gene 1.

Alpha fetoprotein (AFP) elevation 

This may occur in a broad spectrum of conditions:

Alpha fetoprotein (AFP) reduction

This may be seen in pregnancy. 

AFP reduction may be associated with: 

See also

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Article information

rID: 64153
Section: Gamuts, Pathology
Synonyms or Alternate Spellings:
  • Alpha fetoprotein reduction
  • Reduced serum AFP
  • Serum AFP reduction
  • Conditions associated with altered alpha fetoprotein levels
  • Serum AFP elevation
  • Raised AFP
  • Raised serum alpha fetoprotein levels
  • Altered alpha fetoprotein
  • Alpha fetoprotein (AFP) elevation
  • Raised alpha feto protein
  • Raised serum alpha feto protein
  • Alpha fetoprotein (AFP)

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