Last revised by Joshua Yap on 4 May 2023

Alpha-fetoprotein (AFP) is an important plasma protein synthesized by the yolk sac and fetal liver. In adults, its main utility is as a tumor marker, primarily for hepatocellular carcinoma or teratoma. Functionally it is the fetal homologue of albumin, i.e. it acts as a major carrier protein in the antenatal circulation. It is encoded by the AFP gene 1.



This may occur in a broad spectrum of conditions:


This may be seen in pregnancy. 

AFP reduction may be associated with: 

See also

ADVERTISEMENT: Supporters see fewer/no ads

Updating… Please wait.

 Unable to process the form. Check for errors and try again.

 Thank you for updating your details.