Amiodarone deposition in the liver

Last revised by Mostafa Elfeky on 12 Jan 2024

Amiodarone deposition in the liver is one of the complications that can occur with amiodarone therapy. 

Increased density in the liver in patients treated with amiodarone is often described in the literature as amiodarone hepatotoxicity. However, it is often an incidental finding with no symptoms or signs of liver disease ref.

In the majority of patients, it is discovered incidentally during routine testing of liver biochemistry and rarely do the hepatic effects develop into symptomatic liver injury or failure 1-5

While being non-specific, increased hepatic attenuation has been described as one of the effects of amiodarone on the liver 2,3. This, however, may not necessarily imply hepatotoxicity.

There is no published literature showing that dronedarone, a synthetic derivative of amiodarone, produces similar CT appearances. This is likely due to the absence of the iodine moieties in the dronedarone molecule. Nevertheless dronedarone can produce severe hepatotoxicity 6.

ADVERTISEMENT: Supporters see fewer/no ads

Cases and figures

  • Case 1
    Drag here to reorder.
  • Case 2
    Drag here to reorder.
  • Case 3
    Drag here to reorder.
  • Case 4
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.