Amiodarone hepatotoxicity

Amiodarone hepatotoxicity is one of the complications that can occur with amiodarone therapy. 

In the majority of patients, it is discovered incidentally during routine testing of liver biochemistry and rarely do the hepatic effects develop into symptomatic liver injury or failure 1-5

While being non-specific, increased hepatic attenuation has been described as one of the effects of amiodarone on the liver 2,3. This however may not necessarily imply hepatotoxicity.

There is no published literature showing that dronedarone, a synthetic derivative of amiodarone, produces similar CT appearances. This is likely due to the absence of the iodine moieties in the dronedarone molecule. Nevertheless dronedarone can produce severe hepatotoxicity 6.

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Article information

rID: 17359
Synonyms or Alternate Spellings:
  • Amiodarone liver toxicity
  • Dronedarone liver toxicity

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