Amiodarone hepatotoxicity is one of the complications that can occur with amiodarone therapy.
In the majority of patients, it is discovered incidentally during routine testing of liver biochemistry and rarely do the hepatic effects develop into symptomatic liver injury or failure 1-5.
While being non-specific, increased hepatic attenuation has been described as one of the effects of amiodarone on the liver 2,3. This however may not necessarily imply hepatotoxicity.
There is no published literature showing that dronedarone, a synthetic derivative of amiodarone, produces similar CT appearances. This is likely due to the absence of the iodine moieties in the dronedarone molecule. Nevertheless dronedarone can produce severe hepatotoxicity 6.
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- 2. Goldman IS, Winkler ML, Raper SE et-al. Increased hepatic density and phospholipidosis due to amiodarone. AJR Am J Roentgenol. 1985;144 (3): 541-6. AJR Am J Roentgenol (abstract) - Pubmed citation
- 3. Markos J, Veronese ME, Nicholson MR et-al. Value of hepatic computerized tomographic scanning during amiodarone therapy. Am. J. Cardiol. 1985;56 (1): 89-92. Am. J. Cardiol. (link) - Pubmed citation
- 4. Nicholson AA, Caplin JL, Steventon DM. Measurement of tissue-bound amiodarone and its metabolites by computed tomography. Clin Radiol. 1994;49 (1): 14-8. - Pubmed citation
- 5. Rigas B, Rosenfeld LE, Barwick KW et-al. Amiodarone hepatotoxicity. A clinicopathologic study of five patients. Ann. Intern. Med. 1986;104 (3): 348-51. - Pubmed citation
- 6. Rizkallah J, Kuriachan V, Brent Mitchell L. The use of dronedarone for recurrent ventricular tachycardia: a case report and review of the literature. (2016) BMC research notes. 9: 370. doi:10.1186/s13104-016-2116-1 - Pubmed