Amsterdam criteria for HNPCC

The Amsterdam criteria are used in the diagnosis hereditary non polyposis colorectal cancer (HNPCC).

Amsterdam Criteria I

Initial description in 1991:

  • > or equal to 3 relatives with colorectal cancer (CRC)
  • > or equal to 1 case in a first degree relative
  • > or equal to 2 successive generations should be affected
  • > or equal to 1 tumour should be diagnosed before the age of 50 years
  • FAP should be excluded
  • tumours should be confirmed with histology
Amsterdam Criteria II

Revision in 1996, and is one of the most widely used criteria at time of writing (July 2016) alongwith Bethesda guidelines.

  • > or equal to 3 relatives with colorectal cancer (CRC) or with an HNPCC associated cancer
    • endometrial carcinoma
    • small bowel adenocarcinoma
    • ureter or renal pelvis cancer
    • ? 1 case in a first degree relative
  • > or equal to 2 successive generations should be affected
  • > or equal to 1 tumour should be diagnosed before the age of 50 years
  • FAP should be excluded
  • tumours should be confirmed with histology

An alternative criteria scheme is the Bethesda criteria of HNPCC 2

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