Anaplastic ependymoma

Anaplastic ependymomas (WHO grade III ependymomas), in comparison to lower grade ependymomas, are characterised by a higher proliferative rate and a greater tendency to infiltrate surrounding brain or disseminate into cerebrospinal fluid causing drop metastases 1. The relevance of grading ependymomas is questionable, though, and molecular subgroups are likely to carry greater importance 4.

About 25% of ependymomas exhibit features of anaplasia with a high mitotic rate, microvascular proliferation, cellular pleomorphism, and intratumoral necrosis; these are considered WHO grade lll 2.

These tumours have a greater propensity to infiltrate surrounding brain or spinal cord parenchyma and have a higher proliferative rate.

Anaplastic ependymomas have appearances that are similar to grade II ependymomas, although they may have a greater predilection for invading adjacent parenchyma 3,4.

The treatment and prognosis of ependymomas are not clearly influenced by histological grading 4

Share article

Article information

rID: 21749
Tag: cases, refs
Synonyms or Alternate Spellings:
  • Anaplastic ependymomas

Support Radiopaedia and see fewer ads

Cases and figures

  • Drag
    Figure 1: histology
    Drag here to reorder.
  • Updating… Please wait.

    Alert accept

    Error Unable to process the form. Check for errors and try again.

    Alert accept Thank you for updating your details.