Anaplastic gangliogliomas are uncommon aggressive variants of the far more common low-grade ganglioglioma (WHO grade I). The aggressive component is the glial (usually astrocytic) component, which demonstrates nuclear pleomorphism, increased mitotic rate and increased cellularity, as well as microvascular proliferation and necrosis 1.
Note: in the current WHO classification of CNS tumors (2016), no criteria have been agreed upon for a ganglioglioma WHO grade II tumor 1.
- 1. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK "WHO Classification of Tumours of the Central Nervous System. 4th Edition Revised" ISBN: 9789283244929