Anaplastic lymphoma kinase (ALK) gene rearrangements

Dr Henry Knipe and Dr Yuranga Weerakkody et al.

Anaplastic lymphoma kinase (ALK) gene rearrangements are known to occur in association with several tumors. The genes codes for an enzyme called anaplastic lymphoma kinase (ALK) or ALK tyrosine kinase receptor / CD246 which is thought o play a role in the brain development and exerts its effects on specific neurons in the nervous system. Re-arrangements could result in anaplastic lymphoma kinase-1 (ALK-1) protein expression.

The key tumors associated with these rearrangements include:

It is also described in association with:

Clinical importance

Useful in determining the suitability of ALK 1 inhibitor therapy (e.g. crizotinib).

See also

Article information

rID: 69162
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • ALK mutation
  • ALK gene arrangements
  • ALK 1 positivity
  • Anaplastic lymphoma kinase (ALK) positivity
  • Anaplastic lymphoma kinase (ALK) gene rearrangement

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