Anaplastic pleomorphic xanthoastrocytoma

Anaplastic pleomorphic xanthoastrocytomas are a more aggressive and less common version pleomorphic xanthoastrocytoma (PXA)

In the current (2016) WHO classification of CNS tumours, they are considered WHO grade III lesions (whereas pleomorphic xanthoastrocytomas are WHO grade II tumours) 1

As clinical and imaging features are essentially the same as lower grade tumours, they are not repeated here but rather discussed as part of the article on pleomorphic xanthoastrocytoma

Pathology

Anaplastic pleomorphic xanthoastrocytomas are defined as a tumour consistent with a pleomorphic xanthoastrocytoma but with an increased mitotic rate of >5 mitoses per 10 high-power fields 1. Otherwise, histologically they are very similar with lower grade tumours, however, necrosis and vascular proliferation are more common 1. They can be difficult to distinguish from epithelioid glioblastomas 1

Treatment and prognosis

Anaplastic pleomorphic xanthoastrocytomas have a substantially worse prognosis; 40-50% 5-year-survivial compared to ~90% 5-year-survivial for pleomorphic xanthoastrocytomas 1

Astrocytic tumour
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Article Information

rID: 53443
Synonyms or Alternate Spellings:

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