Androgen deprivation therapy (ADT), also called androgen suppression therapy or is a form of treatment in prostate cancer, which basically aims to slow prostate cancer growth by blocking the effect of androgens e.g. testosterone.
Such therapy is mainly used for treating men with intermediate- and high-risk localized prostate cancer in combination with radiotherapy 1,2.
Effects on imaging:
mpMRI
shrinkage of prostate volume 3-7
loss of T2 signal 3,5
increase of ADC values in prostate cancer 5,7
decrease of ADC values of benign prostatic tissue 5-7
reduced DCE of prostate cancer 4,6
PET/CT
- 1. Perlmutter MA, Lepor H. Androgen deprivation therapy in the treatment of advanced prostate cancer. (2007) Reviews in urology. 9 Suppl 1: S3-8. Pubmed
- 2. NICE guideline (May 2019). Prostate cancer: diagnosis and management [NG131]
- 3. M Chen, H Hricak, C L Kalbhen et-al. Hormonal ablation of prostatic cancer: effects on prostate morphology, tumor detection, and staging by endorectal coil MR imaging. (2013) AJR. American journal of roentgenology. 166 (5): 1157-63. doi:10.2214/ajr.166.5.8615261 - Pubmed
- 4. Anwar R. Padhani, A. David MacVicar, Connie J. Gapinski et-al. Husband. Effects of Androgen Deprivation on Prostatic Morphology and Vascular Permeability Evaluated with MR Imaging1. (2001) Radiology. 218 (2): 365-74. doi:10.1148/radiology.218.2.r01ja04365 - Pubmed
- 5. Andreas M. Hötker, Yousef Mazaheri, Junting Zheng et-al. Prostate Cancer: assessing the effects of androgen-deprivation therapy using quantitative diffusion-weighted and dynamic contrast-enhanced MRI. (2015) European Radiology. 25 (9): 2665. doi:10.1007/s00330-015-3688-1 - Pubmed
- 6. T. Barrett, A. B. Gill, M. Y. Kataoka et-al. DCE and DW MRI in monitoring response to androgen deprivation therapy in patients with prostate cancer: A feasibility study. (2012) Magnetic Resonance in Medicine. 67 (3): 778. doi:10.1002/mrm.23062 - Pubmed
- 7. Ah Yeong Kim, Chan Kyo Kim, Sung Yoon Park et-al. Diffusion-Weighted Imaging to Evaluate for Changes From Androgen Deprivation Therapy in Prostate Cancer. (2014) American Journal of Roentgenology. 203 (6): W645-50. doi:10.2214/AJR.13.12277 - Pubmed
- 8. Ali Afshar-Oromieh, Nils Debus, Monika Uhrig et-al. Impact of long-term androgen deprivation therapy on PSMA ligand PET/CT in patients with castration-sensitive prostate cancer. (2018) European Journal of Nuclear Medicine and Molecular Imaging. 45 (12): 2045. doi:10.1007/s00259-018-4079-z - Pubmed
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