Aneurysmal bone cyst

Aneurysmal bone cysts (ABC) are benign expansile tumor-like bone lesions of uncertain etiology, composed of numerous blood-filled channels, and mostly diagnosed in children and adolescents.

Aneurysmal bone cysts are primarily seen in children and adolescents, with 80% occurring in patients less than 20 years of age 8.

Patients may present with pain, which may be of insidious onset or abrupt due to pathological fracture, with a palpable lump or with restricted movement.

Aneurysmal bone cysts consist of blood-filled spaces of variable size that are separated by connective tissue containing trabeculae of bone or osteoid tissue and osteoclast giant cells. They are not lined by endothelium. A fine needle aspiration cytology is usually nondiagnostic, often dominated by fresh blood 7.

Although often primary, up to a third 11 of aneurysmal bone cysts are secondary to an underlying lesion (e.g. fibrous dysplasiaosteosarcoma, giant cell tumor 4, chondromyxoid fibroma 16, non-ossifying fibroma 17, chondroblastoma 18).

A variant of aneurysmal bone cysts is the giant cell reparative granuloma which is usually seen in the tubular bones of the hands and feet as well as in the craniofacial skeleton. Occasionally they are also seen in appendicular long bones where they are known as solid aneurysmal bone cysts. Histologically these two entities are identical 6.

They are typically eccentrically located in the metaphysis of long bones, adjacent to an unfused growth plate. Although they have been described in most bones, the most common locations are 4,8:

  • long bones: 50-60%, typically the metaphysis
    • lower limb: 40%
      • tibia and fibula: 24%, especially proximal tibia
      • femur: 13%, especially proximally
    • upper limb: 20%
  • spine and sacrum: 20-30%
    • especially posterior elements, with extension into the vertebral body in 40% of cases 8
  • craniofacial: jaw, basisphenoid, and paranasal sinuses
  • epiphysis, epiphyseal equivalent, or apophysis: rare but important

Radiographs demonstrate sharply defined, expansile osteolytic lesions, with thin sclerotic margins. CT will demonstrate these findings to a greater degree and is also better at assessing cortical breach and extension into soft tissues.

Additionally, CT can demonstrate fluid-fluid levels, which are harder to appreciate than on MRI and require viewing with a narrow window width 3.

Doughnut sign: increased uptake peripherally with a photopenic center.

MRI is able to demonstrate the characteristic fluid-fluid levels exquisitely as well as identify the presence of a solid component suggesting that the aneurysmal bone cyst is secondary.

The cysts are of a variable signal, with a surrounding rim of low T1 and T2 signal. Focal areas of high T1 and T2 signal 8 are also seen presumably representing areas of blood of variable age (see aging blood on MRI).

It is important to remember that the presence of fluid-fluid levels, although characteristic of aneurysmal bone cysts, is by no means unique to them, and is seen in other lesions as well, both benign and malignant (e.g. giant cell tumors (GCT), chondroblastoma, simple bone cysts and telangiectatic osteosarcomas).

  • T1 (C+): septations may enhance 12

Aneurysmal bone cysts are poorly vascular 15.

Traditionally, these lesions have been treated operatively (curettage and bone grafting) with a recurrence rate of ~20% (range 11-31%). Percutaneous treatment with fibrosing agents has also been performed, either in isolation or as a precursor to surgical excision 1,5.

Spontaneous regression may occur, including following partial removal, but this is not the typical natural history 13,14.

The differential diagnosis depends on the modality.

On plain radiography (and to a lesser degree CT), the diagnosis includes most of the lesions included in the mnemonic FEGNOMASHIC. Compared to the other lesions in this list, aneurysmal bone cysts are markedly expansile (hence, "aneurysmal") and have a thin cortical shell.

On MRI the differential is much shorter, especially when age, location and plain film appearance is taken into account. The main differential includes both lesions with intrinsic fluid-fluid levels (see fluid-fluid level containing bone lesions) and those from which an aneurysmal bone cyst may arise:

Bone tumours

The differential diagnosis for bone tumors is dependent on the age of the patient, with a very different set of differentials for the pediatric patient.

Article information

rID: 894
Synonyms or Alternate Spellings:
  • Aneurysmal bone cyst (ABC)
  • ABC
  • Aneurysmal bone cysts

ADVERTISEMENT: Supporters see fewer/no ads

Cases and figures

  • Case 1: proximal humerus
    Drag here to reorder.
  • Case 2: distal tibia
    Drag here to reorder.
  • Case 3: 4th metacarpal bone
    Drag here to reorder.
  • Case 4: vertebral
    Drag here to reorder.
  • Case 5: 4th metacarpal
    Drag here to reorder.
  • Case 6
    Drag here to reorder.
  • Case 7: with associated GCT
    Drag here to reorder.
  • Case 8
    Drag here to reorder.
  • Case 10: CT proximal fibula
    Drag here to reorder.
  • Case 11: sacrum
    Drag here to reorder.
  • Case 12
    Drag here to reorder.
  • Case 13: proximal tiba
    Drag here to reorder.
  • Case 14
    Drag here to reorder.
  • Case 15: talus
    Drag here to reorder.
  • Case 16
    Drag here to reorder.
  • Case 17
    Drag here to reorder.
  • Case 18
    Drag here to reorder.
  • Case 19: arising in the calcaneus
    Drag here to reorder.
  • Case 20: small aneurysmal bone cyst involving rib
    Drag here to reorder.
  • Case 21
    Drag here to reorder.
  • Case 22
    Drag here to reorder.
  • Case 23
    Drag here to reorder.
  • Case 24
    Drag here to reorder.
  • Case 25
    Drag here to reorder.
  • Case 26
    Drag here to reorder.
  • Case 27
    Drag here to reorder.
  • Case 28: secondary to fibrous dysplasia
    Drag here to reorder.
  • Case 29
    Drag here to reorder.
  • Case 30: left iliac bone
    Drag here to reorder.
  • Case 31: proximal femur
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.