Angiomyofibroblastoma like tumour of scrotum

Dr Amir Rezaee et al.

Angiomyofibroblastoma like tumour of scrotum is a rare well-defined slow growing mesenchymal extratesticular nonepididymal tumour which rarely seen in perineum and scrotum of older male patients. A similar tumour can occur in the vulval region in females.

In males, they are seen in middle age to elderly patients between 45-75 years old. In the majority of cases it has an indolent and nonaggressive clinical course; however, in minority focal invasion and recurrence has been reported. 

  • macroscopic

    • superficial well circumscribed with gray-white to yellow-brown colour.

  • microscopic
    • high vascularity and perivascular fibrinoid hyalinisation

    • tumour cells are spindle cells with minimal atypia and mitosis

    • small amount of fat in 25-56%


Positive for vimentin and negative for S100, actin, and CD 34. 


Heterogeneous echotexture and iso i=echoic to the surrounding tissue and subcutaneous fat. 

CT scan

Well circumscribed homogeneous subcutaneous oval mass with possible several small internal hypodense foci.

  • T1: low due to high fibrous contents
  • T2: intermediate heterogeneous signal

Intense post contrast enhancement due to high vascularity of the lesions.

Treatment is wide surgical resection to reduce recurrence rate. 

In the scrotum, the differential includes rare lesions such as:

  • spindle lipoma of scrotum
  • liposarcoma of scrotum
  • solitary fibrous tumour of scrotum
  • leiomyoma of scrotum 
  • aggressive angiomyxoma of scrotum
Share Article

Article Information

rID: 43881
System: Urogenital
Section: Pathology
Tags: cases, ref
Synonyms or Alternate Spellings:
  • Angiomyofibroblastoma like tumor of scrotum
  • Angiomyofibroblastoma like tumor of the scrotum

Support Radiopaedia and see fewer ads

Updating… Please wait.

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.