Angiomyofibroblastoma-like tumor of scrotum

Angiomyofibroblastoma-like tumor of the scrotum is a rare, well-defined, slow growing mesenchymal extratesticular nonepididymal tumor rarely seen in the perineum or scrotum of older male patients. A similar tumor can occur in females in the vulval region.

In males, they are seen in middle aged to elderly patients between age 45 and 75. In the majority of cases it has an indolent and nonaggressive clinical course; however, focal invasion and recurrence have been reported.

These tumors appear as superficial well-circumscribed masses with a greyish white to yellowish brown color.

Angiomyofibroblastoma-like tumors of the scrotum demonstrate high vascularity and perivascular fibrinoid hyalinisation. The tumor cells are spindle cells with minimal atypia and a low mitotic rate. A small amount of fat is seen in 25-56% of cases. 

Positive for vimentin and negative for S100, actin, and CD34.

Heterogeneous echotexture, isoechoic to the surrounding tissue and subcutaneous fat. 

Well-circumscribed homogeneous subcutaneous oval mass, possibly with several small internal hypodense foci.

  • T1: low due to high fibrous content
  • T2: intermediate heterogeneous signal

Intense postcontrast enhancement due to high vascularity of the lesions.

Treatment is wide surgical resection to reduce recurrence rate.

In the scrotum, the differential includes rare lesions such as:

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Article information

rID: 43881
System: Urogenital
Tag: cases, ref
Synonyms or Alternate Spellings:
  • Angiomyofibroblastoma like tumor of scrotum
  • Angiomyofibroblastoma like tumor of the scrotum
  • Angiomyofibroblastoma-like tumour of the scrotum

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