Angiosarcoma (bone)

Angiosarcoma of bone is a malignant vascular tumour of bone. These are rare and account for less than 1% of malignant bone tumours. The majority of these tumours arising in bone are primary; however, a tiny percentage is either radiation-induced or associated with bone infarction

Most common in young individuals. Males are more commonly affected than females. 

Although there is no particular clinical presentation, the majority of the patients present with a chronic dull pain and/or tumour mass. Other presentations include

  • associated neurological deficits
  • pathological fractures - rare
  • most common sites are short and long tubular bones of extremities 2
    • femur - 23%
    • tibia - 18%
    • humerus - 13%
    • pelvis - 7%

Angiosarcomas can be unifocal or multifocal (up to a 3rd can be multifocal 4)

They are usually purely lytic, eccentric and occur in a metadiaphyseal location. They can have a very aggressive appearance, without a periosteal reaction and less soft tissue extension. 

Can occur as multiple lesions in same bone. 

Metastatic lesions to other skeletal sites may be seen.

In general very poor prognosis and depends on location and extent. Treatment options include:

  • wide surgical excision 
  • limb-sparing surgery
  • radiotherapy

Possible differential considerations include:

Share article

Article information

rID: 25427
Section: Gamuts
Synonyms or Alternate Spellings:
  • Angiosarcoma of bones
  • Primary angiosarcoma of bone
  • Angiosarcoma of the bone

Support Radiopaedia and see fewer ads

Updating… Please wait.

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.