Angiosarcoma of breast

Radswiki et al.

Breast angiosarcomas are a rare vascular breast malignancy.

As primary tumours of the breast, they account for ~0.04% 2 of all breast cancers and tend to occur in younger women, 3rd to 4th decades. Secondary angiosarcoma has an estimated incidence of ~0.09-0.16% and occurs in older women (peak age 6th decade 2).

They tend to present as a painless rapidly growing mass that may be bluish or purple in colour.

The tumours are of endovascular origin. There are two main types:

Location

The tumours tend to be usually cutaneous or subcutaneous in location.

Associations
  • prior breast irradiation: for radiation-induced breast angiosarcoma, tend to occur after a significant latent period after radiation (~5 years)
  • Stewart-Treves syndrome
Mammography

Lesions can sometimes be occult on mammography 7.

Breast MRI

A heterogeneous mass is usually seen on MRI. Reported signal characteristics include 7:

  • T1: usually low signal intensity
  • T2: usually high signal intensity
  • C+ (Gd): low-grade lesions show progressive enhancement whereas high-grade lesions show rapid enhancement and washout

They are extremely aggressive tumours and carry a poor prognosis. A mastectomy is required while axillary nodal dissection is not required due to haematogenous spread.


Breast imaging and pathology
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Article Information

rID: 13965
System: Breast
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Breast angiosarcoma
  • Angiosarcoma of the breast
  • Breast angiosarcomas
  • Angiosarcomas of the breast
  • Angiosarcomas of breast

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