Ankylosing spondylitis

Dr Henry Knipe and A.Prof Frank Gaillard et al.

Ankylosing spondylitis (less commonly known as Bechterew disease and Marie Strümpell disease) is a seronegative spondyloarthropathy, which results in fusion (ankylosis) of the spine and sacroiliac (SI) joints, although involvement is also seen in large and small joints.

There is a male predilection of 3:1 or more. It usually manifests in young adults, with the first symptoms becoming evident in the third decade, although up to 18% of cases manifest in the second decade.

Patients are rheumatoid factor (RF) negative (hence seronegative). HLA B27 is the gene with the strongest association. Other possibly contributing genes include ERAP-1, IL23 Receptor genes and TNF associated genes 22. Although approximately 90% of Caucasian individuals with ankylosing spondylitis have the HLA-B27 gene, it is important to note this gene is present in 8-9% of people of Northern European ancestry 5. Overall, ~5% of people positive for HLA-B27 develop ankylosing spondylitis. 

The axial skeleton is predominantly affected, although in ~20% of cases the peripheral joints are also involved.

  • sacroiliitis is usually the first manifestation 5 and is symmetrical and bilateral
    • the sacroiliac (SI) joints first widen before they narrow
    • subchondral erosions, sclerosis and proliferation on the iliac side of the SI joints
    • at end-stage, the SI joint may be seen as a thin line or not visible

See: grading of sacroiliitis

Hip involvement is generally bilateral and symmetric, with uniform joint space narrowing, axial migration of the femoral head sometimes reaching a state of protrusio acetabuli, and a collar of osteophytes at the femoral head-neck junction.

There can be bridging or fusion of the pubic symphysis.

Knees demonstrate uniform joint space narrowing with bony proliferation.

Hands are generally involved asymmetrically, with smaller, shallower erosions and marginal periostitis.

Shoulder joint involvement is not uncommon and demonstrates a large erosion of the anterolateral aspect of the humeral head, producing a 'hatchet' deformity.

see: thoracic manifestations of ankylosing spondylitis

Radiographs of the lungs may demonstrate progressive fibrosis and bullous changes at the apices. These lesions may resemble tuberculosis infection and bullae may become infected.

  • may be useful in selected patients with normal or equivocal findings on sacroiliac joint radiographs
  • chronic structural changes such as joint erosions, subchondral sclerosis, and bony ankylosis are better visualised on CT than on MRI or radiographs 15-17
  • some normal variants of the SI joints may mimic features of sacroiliitis
  • supplements scintigraphy in evaluating areas of increased uptake
  • superior to radiographs and MRI in demonstrating injuries
    • imaging modality of choice in patients with advanced ankylosing spondylitis in whom there is suspicion of cervical spine fracture
    • sagittal reformats should be obtained as axial images poorly assess the transverse fracture plane
  • may have a role in early diagnosis of sacroiliitis; MRI is more sensitive than CT or plain radiography in detecting inflammatory changes (which precede structural changes) such as bone marrow edema (best demonstrated on STIR sequences), synovitis and capsulitis (on gadolinium enhanced T1 weighted sequences) 16,18
  • synovial enhancement on MR correlates with disease activity measured by inflammatory mediators
  • enhancement of the interspinous ligaments is indicative of enthesitis
  • increased T2 signal correlates with oedema or vascularised fibrous tissue
  • superior to CT in the detection of cartilage inflammation and destruction
  • useful in following treatment results in patients with active ankylosing spondylitis
  • may be helpful in selected patients with normal or equivocal findings on sacroiliac joint radiographs
  • qualitative assessment of accumulation of radionuclide in the SI joints may be difficult due to normal uptake in this location; thus, quantitative analysis may be more useful
  • ratios of SI joint to sacral uptake of 1.3:1 or higher is abnormal

First-line therapy is primarily focused on NSAIDs and non-pharmacological measures including education, exercise, physiotherapy and group-therapy. Together, these treatments can lead to substantial clinical improvement in 70-80% of patients. Local steroid injection and DMARDs (sulfasalazine and methotrexate) can also help with peripheral manifestations. Second-line therapy includes TNF-alpha blockers (etanercept, infliximab, adalimumab, certolizumab, golimumab) and IL17 inhibitors (secukinumab) 24. Whether TNF-alpha blockers can inhibit radiographic disease progression has been the subject of some debate and continues to be investigated 23.

  • fracture
    • diffuse paraspinal ossification and inflammatory osteitis creates a fused, brittle spine, susceptible to fracture, even with minor trauma
    • more common at the thoracolumbar and cervicothoracic junctions
    • recognition of minimally displaced fractures is difficult due to osteopenia and deformity, and it is important to specifically search for disk space widening and discontinuity of the ossified paraspinal ligaments
      • also known as "chalk stick" or "carrot stick fractures" 19
  • Andersson lesion: inflammatory spondylodiscitis that occurs in association with ankylosing spondylitis and results in a disc pseudarthrosis
  • rare neurological complications include transverse myelitis and/or cauda equina syndrome 20, 21
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Article information

rID: 904
Section: Radiography
Synonyms or Alternate Spellings:
  • Bechterew disease
  • Marie Strümpell disease
  • Ankylosing spondylosis

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Cases and figures

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    Case 1: with dagger spine
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    Sij Grade4

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    Case 18: with pseudoarthrosis
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    Case 19: with hip joint involvement
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    Case 20: with dagger sign
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    Case 21
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    Case 22: bilateral sacroiliitis
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    Case 23: with pulmonary fibrosis
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    Case 26: dagger sign
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    Case 28: carrot stick fracture - ankylosing spondylitis
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    Case 30: with apophyseal arthritis
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    Case 31: with dagger sign
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