Antenatal soft markers on ultrasound

Antenatal soft ultrasound markers are fetal sonographic findings that are generally not abnormalities as such but are indicative of an increased age adjusted risk of an underlying fetal aneuploidic or some non chromosomal abnormalities.

Most of the described features do not constitute a structural defect and may be detected on antenatal screening, typically during a second trimester (anatomy) scan. Many are transient.

What's included or not appears to depend on the respective authorities in each region, and remains dynamic, with certain markers periodically emerging, or conversely losing favour. 

The following are markers in common use at the time of writing. The list includes features having an association with:

An increased risk of aneuploidy and in some cases non-chromosomal problems 
An increased risk of non-chromosomal abnormalities when seen in isolation
Soft markers of undefined association

Correct interpretation of these often requires correlation with other risk factors such as history, maternal age and maternal serological results.


Ultrasound - obstetric
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Article Information

rID: 13183
System: Obstetrics
Synonyms or Alternate Spellings:
  • Soft antenatal sonographic markers
  • Soft markers on antenatal ultrasound
  • Soft signs in antenatal ultrasound

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