Antenatal soft markers on ultrasound
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Antenatal soft ultrasound markers are fetal sonographic findings that are generally not abnormalities as such but are indicative of an increased age-adjusted risk of an underlying fetal aneuploidic or certain non-chromosomal abnormalities.
What is included or not appears to depend on the respective authorities in each region, and remains dynamic, with certain markers periodically emerging, or conversely losing favor.
The following are markers in common use at the time of writing. The list includes features having an association with:
An increased risk of aneuploidy and in some cases non-chromosomal abnormalities
increased nuchal thickness: >6 mm
fetal ventriculomegaly: >10 mm
shortened fetal long bones: less than 3rd centile for gestational age
An increased risk of non-chromosomal abnormalities when seen in isolation
Soft markers of undefined association
Correct interpretation of these often requires correlation with other risk factors such as history, maternal age, and maternal serological results.
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