Anterior cerebral artery

Last revised by Rohit Sharma ◉ on 28 May 2024

The anterior cerebral artery (ACA), along with the middle cerebral artery (MCA) forms at the termination of the internal carotid artery (ICA). It is the smaller of the two and arches anteromedially to pass anterior to the genu of the corpus callosum, dividing as it does so into its two major branches: the pericallosal and callosomarginal arteries. 

It supplies the medial aspect of the cerebral hemispheres back to the parietal lobe.

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The anterior cerebral artery is divided into five segments 8-10:

  • A1: horizontal or pre-communicating segment

  • A2: vertical, post-communicating or infracallosal segment

    • originating at the anterior communicating artery, extending anterior to the lamina terminalis and along the rostrum of the corpus callosum

    • terminates either at the junction of the rostrum and genu of the corpus callosum at the apex of the dorsal convex arch, or at the origin of the callosomarginal artery

  • A3: precallosal segment

    • extends around the genu of the corpus callosum, or originates distal to the origin of the callosomarginal artery

    • terminates where the artery turns directly posterior above the body of the corpus callosum

  • A4: supracallosal segment

    • above the body of the corpus callosum anterior to the plane of the coronal suture

  • A5: ​postcallosal segment

    • above the body of the corpus callosum posterior to the plane of the coronal suture

The pericallosal artery refers either to the distal part of the ACA starting from A2 (after the origin of the anterior communicating artery) or from A3 (defined after the origin of the callosomarginal artery). In the former case, the A2, A3, and A4-5 segments refer to proximal, middle, and distal segments of the pericallosal artery, respectively 11,12.

The A4 and A5 segments predominantly run along the callosal sulcus, but in a minority of cases run above that, medial to the cingulate gyrus.

There are two main branching patterns of the anterior cerebral artery. In the first, the A2 gives off the callosomarginal artery (which lies in the cingulate sulcus) and continues as the pericallosal artery. In this configuration, the terminal (cortical) branches arise from the callosomarginal artery.

In the second configuration, the callosomarginal artery is absent and the terminal branches arise directly from the pericallosal artery.

Orbital branches, 2 or 3 in number, branch over the orbital surface of the frontal lobe supplying:

They are named:

Frontal branches supply:

Parietal branches supply:

Multiple small branches are given off proximally (A1, ACom, proximal A2) supply:

The latter two - head of caudate and adjacent part of the internal capsule - are supplied by the recurrent artery of Heubner and associated smaller perforating branches. It has its origin near the A1-ACom-A2 junction and can arise from all three, although usually, it is from the A2. It curves back on itself and is at risk of ACom aneurysm clipping.

  • ACA fenestration with a reported incidence of 0-4% of A1 segment fenestration

  • azygos ACA: ACA territories supplied by a single A2 trunk; incidence of ~2% (range 0.2-4%)

  • ACA trifurcation: three A2 segments; incidence of ~7.5% (range 2-13%)

  • bihemispheric ACA: a hypoplastic A2 segment with contralateral A2 segment dominance supplying both ACA territories; incidence of ~4.5% (range 2-7%)

  • A1 segment absence/hypoplasia, contralateral A1 segment dominance and supply to ipsilateral A2 segment by a large anterior communicating artery: 10% of individuals demonstrate hypoplasia of A1 segment using a diameter 1.5 mm or smaller

  • duplication of A1

  • two or three anterior communicating arteries

  • asymmetry of A1 segment which is associated with ACA aneurysm

  • persistent primitive olfactory artery 6

  • infraoptic ACA: A1 travels inferior or through the optic nerve 13

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