Anti-GQ1b IgG antibody syndrome
Anti-GQ1b IgG antibody syndrome refers to a number of conditions which share autoantibodies to the ganglioside complex GQ1b, and have overlapping clinical spectrums.
The conditions believed to represents various clinical manifestations of a common immunological disorder include 1:
- acute ophthalmoparesis without ataxia
- Bickerstaff brainstem encephalitis
- Guillain-Barré syndrome
- Miller Fisher syndrome
The exact relationship between these entities, and what determines the clinical phenotype remains unclear, possibly relating to the exact specificity of the anti-GQ1b antibodies and how these are expressed throughout the nervous system 2.
- 1. Odaka M, Yuki N, Hirata K. Anti-GQ1b IgG antibody syndrome: clinical and immunological range. Journal of neurology, neurosurgery, and psychiatry. 70 (1): 50-5. Pubmed
- 2. Fukami Y, Wong AH, Funakoshi K, Safri AY, Shahrizaila N, Yuki N. Anti-GQ1b antibody syndrome: anti-ganglioside complex reactivity determines clinical spectrum. European journal of neurology. 23 (2): 320-6. doi:10.1111/ene.12769 - Pubmed