Anti-Jo-1 antibody positive interstitial lung disease

Last revised by Yuranga Weerakkody on 6 Feb 2023

Anti-Jo-1 antibody positive interstitial lung disease refer to cases of interstitial lung disease occurring in the setting on anti-Jo-1 antibody positivity.

Anti-Jo-1 antibody positivity has a recognized association with interstitial lung disease. This most commonly occurs in a setting of polymyositis or dermatomyositis but can also occur in other situations such as antisynthetase syndrome.

According to once study a non-specific interstitial pneumonia (NSIP) pattern was considered the most common pattern (52%), followed by NSIP overlapping with organizing pneumonia (OP) pattern (22%) 6.

This condition has a variable prognosis. Treatment with corticosteroids and immunosuppressent drugs is often considered required in most patients 3

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