Anti-Jo-1 antibody positive interstitial lung disease
Anti-Jo-1 antibody positivity has a recognized association with interstitial lung disease. This most commonly occurs in a setting of polymyositis or dermatomyositis but can also occur in other situations such as antisynthetase syndrome.
Treatment and prognosis
This condition has a variable prognosis. Treatment with corticosteroids and immunosuppressive drugs is often considered required in most patients 3.
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- 4. Maki Tanaka, Machiko Arita, Hiromasa Tachibana, Tadashi Ishida, Takashi Nakazawa. Clinical features and CT findings of anti-Jo-1 antibody positive interstitial lung disease with or without polymyositis and dermatomyositis. (2013) European Respiratory Journal. 42 (Suppl 57): P3810.
- 5. I. Marie, S. Josse, P. Y. Hatron, S. Dominique, E. Hachulla, A. Janvresse, P. Cherin, L. Mouthon, O. Vittecoq, J.‐F. Menard, F. Jouen. Interstitial Lung Disease in Anti–Jo‐1 Patients With Antisynthetase Syndrome. (2013) Arthritis Care & Research. 65 (5): 800. doi:10.1002/acr.21895 - Pubmed