Anti-Jo-1 antibody positive interstitial lung disease

Last revised by Assoc Prof Craig Hacking on 18 Aug 2021

Anti-Jo-1 antibody positive interstitial lung disease refer to cases of interstitial lung disease occurring in the setting on anti-Jo-1 antibody positivity.


Anti-Jo-1 antibody positivity has a recognized association with interstitial lung disease. This most commonly occurs in a setting of polymyositis or dermatomyositis but can also occur in other situations such as antisynthetase syndrome.

Treatment and prognosis

This condition has a variable prognosis. Treatment with corticosteroids and immunosuppressent drugs is often considered required in most patients 3

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Cases and figures

  • Case 1: anti-synthetase syndrome
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