Anti melanoma differentiation associated gene 5 (MDA5) antibody positive clinically amyopathic dermatomyositis

Anti-MDA5 antibody-positive amyopathic dermatomyositis is a subtype of dermatomyositis where there is positivity to an anti-melanoma differentiation-associated gene 5 (MDA5) antibody. It has been reported to be associated with rapidly progressive interstitial lung disease (RP-ILD) resulting in high mortality. On thoracic imaging, patient's may show rapidly progressive interstitial changes (sometimes associated with pneumomediastinum +/- pneumothoraces) and have respiratory failure.

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rID: 68912
Synonyms or Alternate Spellings:
  • Anti-MDA5 antibody-positive amyopathic dermatomyositis
  • Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive clinically amyopathic dermatomyositis
  • Anti melanoma differentiation associated gene 5 (mda5) antibody positive clinically amyopathic dermatomyositis (CADM)

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