Anti-synthetase syndrome

Anti-synthetase syndrome (ASS) is a systemic, inflammatory, autoimmune disease that is characterised by inflammatory myositis, polyarthritis associated with interstitial lung disease (ILD) and anti-synthetase autoantibodies.

Pathology

ASS can result from autoantibodies to eight of the aminoacyl-transfer RNA synthetases. These include:

Radiographic features

Imaging findings vary depending on the organ involved. 

Chest
CT

The associated interstitial lung disease may usually give either a NSIP pattern, an organising pneumonia pattern or a combination 6. A UIP pattern may also occasionally occur 8. The consolidative regions may decrease or resolve in many cases although the disease can at times progress to fibrosis in more than one third of patients.

Share article

Article information

rID: 17810
System: Chest
Section: Syndromes
Tag: cases
Synonyms or Alternate Spellings:
  • Anti synthetase syndrome (ASS)

Support Radiopaedia and see fewer ads

Cases and figures

  • Drag
    Case 1: with anti-Jo1 elevation
    Drag here to reorder.
  • Drag
    Case 1: with anti-Jo1 elevation
    Drag here to reorder.
  • Drag
    Case 2
    Drag here to reorder.
  • Updating… Please wait.
    Loadinganimation

    Alert accept

    Error Unable to process the form. Check for errors and try again.

    Alert accept Thank you for updating your details.