Anti-synthetase syndrome

Anti-synthetase syndrome (ASS) is a systemic, inflammatory, autoimmune disease that is characterized by inflammatory myositis, polyarthritis associated with interstitial lung disease (ILD) and anti-synthetase autoantibodies.

ASS can result from autoantibodies to eight of the aminoacyl-transfer RNA synthetases. These include:

Imaging findings vary depending on the organ involved. 

The associated interstitial lung disease may usually give either a NSIP pattern, an (OP) organizing pneumonia pattern or a combination (NSIP-OP pattern) 6. A UIP pattern may also occasionally occur 8. The consolidative regions may decrease or resolve in many cases although the disease can at times progress to fibrosis in more than one third of patients.

Some medications used include 9: Corticosteroids, Azathioprine, Mycophenolate mofetil (MMF), calcineurin inhibitors: Tacrolimus and Cyclosporine, Rituximab, Cyclophosphamide and intravenous immunoglobulin (IVIG).

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Article information

rID: 17810
System: Chest
Section: Syndromes
Tag: cases
Synonyms or Alternate Spellings:
  • Anti synthetase syndrome (ASS)
  • Antisynthetase syndrome

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Cases and figures

  • Case 1: with anti-Jo1 elevation
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  • Case 1: with anti-Jo1 elevation
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  • Case 2
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