HALF PRICE OFFER ENDS TODAY! New Elbow X-ray Interpretation Course by Andrew Murphy REGISTER NOW

Anti-synthetase syndrome

Anti-synthetase syndrome (ASS) is a systemic, inflammatory, autoimmune disease that is characterized by inflammatory myositis, polyarthritis associated with interstitial lung disease (ILD), and anti-synthetase autoantibodies.

Anti-synthetase syndrome can result from autoantibodies to eight of the aminoacyl-transfer RNA synthetases. These include:

Imaging findings vary depending on the organ involved. 

The associated interstitial lung disease of anti-synthetase syndrome may usually give either a NSIP pattern, an organizing pneumonia (OP) pattern or a combination of the two (NSIP-OP pattern) 6. A UIP pattern may also occasionally occur 8. The consolidative regions may decrease or resolve in many cases although the disease can at times progress to fibrosis in more than one third of patients.

Medications used for anti-synthetase syndrome include corticosteroids, azathioprine, mycophenolate mofetil (MMF), calcineurin inhibitors (tacrolimus and cyclosporine), rituximab, cyclophosphamide and intravenous immunoglobulin (IVIG) 9.

Article information

rID: 17810
System: Chest
Section: Syndromes
Tag: cases, cases
Synonyms or Alternate Spellings:
  • Anti synthetase syndrome (ASS)
  • Antisynthetase syndrome

ADVERTISEMENT: Supporters see fewer/no ads

Cases and figures

  • Case 1: with anti-Jo1 elevation
    Drag here to reorder.
  • Case 1: with anti-Jo1 elevation
    Drag here to reorder.
  • Case 2
    Drag here to reorder.
  • Updating… Please wait.

     Unable to process the form. Check for errors and try again.

     Thank you for updating your details.