Antiphospholipid syndrome

Antiphospholipid syndrome is a systemic autoimmune disorder. It is usually defined as the clinical complex of vascular occlusion and ischaemic events occurring in patients who have circulating antiphospholipid antibodies.

Antiphospholipid syndrome is characterised by venous, arterial, or small vessel thrombosis, potentially affecting multiple organ systems:

Patients have circulating antiphospholipid antibodies cross-react with cell membrane phospholipids. This results in a hypercoagulable state leading to vascular thrombosis. 

The disorder can be primary (primary antiphospholipid syndrome) or secondary (i.e. associated with systemic lupus erythematosus).

Positive lupus anticoagulant, anticardiolipin antibodies, and anti-beta2-glycoprotein I antibodies are seen but are not specific for antiphospholipid syndrome if considered in isolation (see diagnostic criteria below) 6. Paradoxically, if lupus anticoagulant is present, a patient's coagulation profile will show an elevated aPTT suggesting a propensity to bleeding, however this is not the case.

Diagnosis is made using the revised Sapporo criteria, in which patients need to meet at least one clinical and at least one laboratory criteria to fulfil the diagnosis of antiphospholipid syndrome 7.

  • clinical criteria 7:
    • vascular thrombosis: ≥1 episode of venous, arterial, or small vessel thrombosis in any tissue or organ
    • pregnancy morbidity: 3 miscarriages <10 weeks, or 1 miscarriage ≥10 weeks, or premature birth before 34 weeks
  • laboratory criteria (detected on ≥2 occasions on testing at least 12 weeks apart) 7:
    • anticoardiolipin antibodies
    • anti-beta2-glycoprotein I antibodies
    • lupus anticoagulant

Asymptomatic antiphospholipid syndrome does not warrant any antiplatelet or antithrombotic therapy 8. However, warfarin is used for acute thromboembolic events or as secondary prevention 8. Management of organ-specific manifestations of antiphospholipid syndrome are beyond the scope of this general article. Less than 1% of patients may develop the more serious and fatal catastrophic antiphospholipid syndrome.

Article information

rID: 26162
Section: Syndromes
Synonyms or Alternate Spellings:
  • Anti-phopholipid antibody syndrome
  • Antiphospholipid syndrome (APS)
  • Hughes syndrome
  • Anti-phopholipid syndrome
  • APLA syndrome
  • Anti phospholipid antibody syndrome

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Cases and figures

  • Case 1: diffuse alveolar haemorrhage
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  • Case 2: pulmonary embolism
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  • Case 3: renal vein thrombosis
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  • Case 4: bithalamic infarction
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  • Case 5: superior mesenteric vein thrombosis
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