Aortoiliac occlusive disease refers to complete occlusion of the aorta distal to the renal arteries.
When the clinical triad of impotence, pelvis and thigh claudication, and absence of the femoral pulses are present, it may also be called Leriche syndrome, which usually affects younger (30-40 year old) males 9.
Aortoiliac occlusive disease is more common in the elderly with an advanced atherosclerotic disease. Acute onset is more common in female patients and is associated with poor outcome with approximately 50% mortality.
In acute cases, symptoms include the 6 Ps:
In chronic onset cases, mostly in arteriosclerosis, symptoms may include erectile dysfunction or impotence, claudication and absence of femoral pulses 11.
The anatomical location of atheromatous lesions influence the classification and treatment choice 12:
- type I: confined to distal abdominal aorta and common iliac arteries
- type II: as above with extension into the external iliac arteries
- type III: aortoiliac segment and femoropopliteal vessels
According to the Trans Atlantic Inter Society Consensus II (TASC II) Leriche syndrome is a type D lesion 13.
The condition can be acute or chronic. There is endothelial damage resulting in inflammation and lipid accumulation in the tunica media and macrophages eventually leading to plaque formation and occlusive disease 11. Complete infra-renal aortoiliac occlusion will display significant collateral circulation sustained by multiple anastomoses allowing reconstitution with the distal femoral arteries 13.
Most often the occlusion occurs near the aortic bifurcation. It typically begins at the distal aorta or common iliac artery origins and slowly progresses proximally and distally over time.
- arteriosclerosis: the main cause of this syndrome is an atherosclerotic obstruction of aortoiliac arteries 2
An extensive network of collateral parietal and visceral vessels may form to bypass any segment of the aortoiliac arterial system. In abdominal aortoiliac stenosis/occlusion, the commonest collateral pathways to the lower extremities are 5:
- superior mesenteric artery > inferior mesenteric artery > superior rectal artery >
- intercostal, subcostal, and lumbar arteries > superior gluteal and iliolumbar arteries > internal iliac arteries > external iliac arteries.
- intercostal, subcostal, and lumbar arteries > circumflex arteries > external iliac arteries
- subclavian arteries > internal thoracic (mammary) arteries > superior epigastric arteries > inferior epigastric arteries > external iliac arteries (the Winslow Pathway 7)
CT angiography is usually the best modality for assessment. In patients where CT is not possible, contrast-enhanced MR angiography may be a good option 4.
It allows direct anatomical visualization of the location of the stenosis and occlusion. It also permits the assessment for the presence of a concomitant occlusive disease affecting visceral arteries, the type and extent of collateralization, and the level of the most proximal and distal arterial segments amenable to stent-graft placement.
Treatment and prognosis
Traditional surgical procedures for aortoiliac occlusive disease are 8 :
- aortoiliac endarterectomy (TEA)
- aortobifemoral bypass (AFB)
- patency rates of 90% at five years and 80% at ten years 11
- Tasc II type D lesions recommend surgery as the treatment of choice 13
- axillobifemoral bypass (extra-anatomic technique); used to avoid abdominal surgery
- percutaneous transluminal angioplasty (PTA) and stenting
Other more novel methods include
- covered endovascular reconstruction of aortic bifurcation (CERAB) technique
History and etymology
It is named after French vascular surgeon René Leriche (1879–1955) who initially described the findings in 1948 3.
Imaging differential considerations include:
- mid-aortic syndrome: occurs at or above renal artery level with the involvement of a longer segment and usually in much younger patients (usually 10-30 years old)
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- 7. Prager RJ, Akin JR, Akin GC, Binder RJ. Winslow's pathway: a rare collateral channel in infrarenal aortic occlusion. AJR Am J Roentgenol. 1977 Mar;128 (3): 485-7. Pubmed citation
- 8. Lee WJ, Cheng YZ, Lin HJ. Leriche syndrome. Int J Emerg Med. 2008;1 (3): 223. doi:10.1007/s12245-008-0039-x - Free text at pubmed - Pubmed citation
- 9. Peripheral vascular interventions. LWW. ISBN:0781786878. Read it at Google Books - Find it at Amazon
- 10. Hardman RL, Lopera JE, Cardan RA, Trimmer CK, Josephs SC. Common and rare collateral pathways in aortoiliac occlusive disease: a pictorial essay. (2011) AJR. American journal of roentgenology. 197 (3): W519-24. doi:10.2214/AJR.10.5896 - Pubmed
- 11. Kristen N. Brown, Lorena Gonzalez. Leriche Syndrome. (2019) Pubmed
- 12. Candace Wooten, Munawar Hayat, Maira du Plessis, Alper Cesmebasi, Michael Koesterer, Kevin P. Daly, Petru Matusz, R. Shane Tubbs, Marios Loukas. Anatomical significance in aortoiliac occlusive disease. (2014) Clinical Anatomy. 27 (8): 1264. doi:10.1002/ca.22444 - Pubmed
- 13. Laganà D, Ciranni S, Minici R, Mazzarella G. Leriche Syndrome: Percutaneous Treatment with Mechanical Thrombectomy: A Case Report. (2018) Journal of Case Reports and Studies. 6 (1): 1. doi:10.15744/2348-9820.6.101
- 14. Goverde PC, Grimme FA, Verbruggen PJ, Reijnen MM. Covered endovascular reconstruction of aortic bifurcation (CERAB) technique: a new approach in treating extensive aortoiliac occlusive disease. (2013) The Journal of cardiovascular surgery. 54 (3): 383-7. Pubmed
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