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Apparent diffusion coefficient

Apparent diffusion coefficient (ADC) is a measure of the magnitude of diffusion (of water molecules) within tissue, and is commonly clinically calculated using MRI with diffusion-weighted imaging (DWI) 1


Diffusion-weighted imaging (DWI) is widely appreciated as an indispensable tool in the examination of the CNS. It is considered useful not only for the detection of acute ischemic stroke but also for the characterization and differentiation of brain tumors and intracranial infections.

DWI exploits the random motion of water molecules. The extent of tissue cellularity and the presence of intact cell membrane help determine the impedance of water molecule diffusion. This impedance of water molecules diffusion can be quantitatively assessed using the apparent diffusion coefficient (ADC) value. This assessment can be done using different b values via changing gradient amplitude 2,3,6. 


ADC values are calculated automatically by the software and then displayed as a parametric map that reflects the degree of diffusion of water molecules through different tissues. Then, by use of a dedicated workstation, ADC measurements are recorded for a given region by drawing regions of interest (ROIs) on the ADC map 6.

An ADC of tissue is expressed in units of mm2/s. There is no unanimity regarding the boundaries of the range of normal diffusion, but ADC values less than 1.0 to 1.1 x 10-3 mm2/s (or 1000-1100 x 10-6 mm2/s) are generally acknowledged in adults as indicating restriction. However, this is entirely dependent on the organ being imaged and the pathology 7.

Some rough useful values (10-6 mm2/s) 8-10:

  • white matter: 670-800
  • deep grey matter: 700-850 
  • cortical grey matter: 800-1000
  • CSF: 3000-3400
  • astrocytoma
    • Grade II: 1273 ± 293
    • Grade III: 1067 ± 276
    • Grade IV: 745 ± 135

Diffusion changes are correlated to the clinical deficit and are potentially useful for early diagnosis and longitudinal evaluation, especially in the context of pharmacological trials.

Imaging technology

Article information

rID: 21759
Tag: dwi
Synonyms or Alternate Spellings:
  • ADC
  • ADC map
  • ADC maps
  • Apparent diffusion coefficient
  • Apparent diffusion coefficient map
  • Apparent diffusion coefficient maps
  • Apparent diffusion coefficient map (ADC map)

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Cases and figures

  • Case 1: cerebral abscess
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  • Case 2: intracranial epidermoid cyst
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  • Case 3: cerebellar abscesses
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  • Case 4: ischemic stroke
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  • Case 5: primary CNS lymphoma
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  • Case 6: Glioblastoma IDH-1 wildtype
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  • Case 7: hepatocellular carcinoma with bland thrombus
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