Arachnoid cysts are relatively common benign and asymptomatic lesions occurring in association with the central nervous system, both within the intracranial compartment (most common) as well as within the spinal canal. They are usually located within the subarachnoid space and contain CSF.
On imaging, they are characterized as well circumscribed cysts, with an imperceptible wall, displacing adjacent structures, and following the CSF pattern (hypodense on CT and hyperintense on T2 with FLAIR suppression on MRI). They can also have a remodeling effect on the adjacent bone.
In a retrospective cohort study of 48,417 patients who underwent neuroimaging, arachnoid cysts were identified in 661 patients (1.4%) with a statistically significant male predilection 4.
The majority of arachnoid cysts are small and asymptomatic. Approximately 5% of patients experience symptoms and when symptoms occur, they are usually the result of gradual enlargement resulting in mass effect 4. This results in either direct neurological dysfunction or distortion of normal CSF pathways resulting in obstructive hydrocephalus 3. Sellar/suprasellar, quadrigeminal, and cerebellopontine angle arachnoid cysts were more likely to be symptomatic 4.
Arachnoid cysts are thought to arise due to the congenital splitting of the arachnoid layer with accumulation of CSF within this potential space. The cyst wall is comprised of flattened arachnoid cells forming a thin translucent membrane. There is no solid component and no epithelial lining.
Arachnoid cysts can occur anywhere within the central nervous system, most frequently (50-60%) located in the middle cranial fossa, where they invaginate into and widen the sylvian fissure. In this location, they can be classified into three types based on their size: see Galassi classification. Of these, Galassi type I is most common accounting for 78% followed by Galassi II and III with 19% and 3% respectively 4. The retrocerebellar location accounts for 30-40% of arachnoid cysts 4.
Some locations deserve special mention and separate discussion:
- suprasellar cistern (see suprasellar arachnoid cyst)
- within the ventricles (see intraventricular arachnoid cyst)
- posterior fossa
- spinal canal (see spinal arachnoid cysts)
Arachnoid cysts are extremely well circumscribed, with an imperceptible wall, and displace adjacent structures. When large, and over time, they can exert a remodeling effect on the bone.
CT cisternography (introduction of contrast into the subarachnoid space) demonstrates communication of the cyst with the subarachnoid space. As this communication is slow, the cyst often fills later, and contrast may be seen to pool with it, outlining its dependent portion.
As they are filled with CSF, it is not surprising that they follow CSF on all sequences, including FLAIR and DWI. This enables them to be distinguished from epidermoid cysts for example. As their wall is very thin it only occasionally can be seen, and displacement of surrounding structures implies their presence. As there is no solid component, no enhancement can be identified.
Phase contrast imaging can also be employed not only to determine if the cyst communicates with the subarachnoid space, but also to identify the location of this communication.
Magnetic resonance cisternography: high resolution sequences such as CISS & FIESTA help to delineate cyst wall and adjacent anatomic structures.
Treatment and prognosis
Arachnoid cysts are benign, and the vast majority remain asymptomatic throughout life. If they are deemed to be causing symptoms, then surgery can be contemplated. This can either take the form of a craniotomy (fenestration or excision) or placement of a cystoperitoneal shunt.
A rare complication is spontaneous rupture in the subdural space.6
History and etymology
Richard Bright was the first to describe an arachnoidal cyst in 1831 5.
General imaging differential considerations include:
- enlarged CSF space (e.g. mega cisterna magna)
- often shows a heterogeneous/dirty signal on FLAIR
- restricted diffusion
- more lobulated
- tend to engulf adjacent arteries and cranial nerves
subdural hygroma/chronic subdural hemorrhage
- do not typically show CSF signal intensity on MRI
- can have an enhancing membrane
- cystic tumors: often will have a solid/enhancing component and be intra-axial
- non-neoplastic cysts
- small cyst
- usually multiple when in the subarachnoid space
- 1. Osborn AG, Preece MT. Intracranial cysts: radiologic-pathologic correlation and imaging approach. Radiology. 2006;239 (3): 650-64. doi:10.1148/radiol.2393050823 - Pubmed citation
- 2. Yildiz H, Erdogan C, Yalcin R et-al. evaluation of communication between intracranial arachnoid cysts and cisterns with phase-contrast cine MR imaging. AJNR Am J Neuroradiol. 2005;26 (1): 145-51. AJNR Am J Neuroradiol (full text) - Pubmed citation
- 3. Kornienko VN, Pronin IN. Diagnostic Neuroradiology. Springer Verlag. (2008) ISBN:3540756523. Read it at Google Books - Find it at Amazon
- 4. Al-Holou WN, Terman S, Kilburg C, Garton HJ, Muraszko KM, Maher CO. Prevalence and natural history of arachnoid cysts in adults. (2013) Journal of neurosurgery. 118 (2): 222-31. doi:10.3171/2012.10.JNS12548 - Pubmed
- 5. Jafrani R, Raskin JS, Kaufman A, Lam S. Intracranial arachnoid cysts: Pediatric neurosurgery update. (2019) Surgical neurology international. 10: 15. doi:10.4103/sni.sni_320_18 - Pubmed
- A. Hall, M. A. J. White, L. Myles. Spontaneous subdural haemorrhage from an arachnoid cyst: a case report and literature review. (2016) British Journal of Neurosurgery. 87 (6): 40-44. doi:10.17116/terarkh201587640-44 - Pubmed