Asbestos related diffuse pleural thickening
Citation, DOI & article data
They may co-exist with pleural plaques but if thought to occur from a different pathology.
Generation of reactive oxygen and nitrogen species, profibrotic cytokines and growth factors in response to asbestos is likely to play a role in the formation of a fibrinous intrapleural matrix 1.
- benign asbestos related pleural effusions: can commonly antedate the development of diffuse pleural thickening 1
pleural mesothelioma: has invasive features
- in concerning cases serial CT imaging or PET-CT may play a role in differentiation.
For a broader differential, consider other forms of diffuse pleural thickening.
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- 2. PA Gevenois, V de Maertelaer, A Madani, C Winant, G Sergent, P De Vuyst. Asbestosis, Pleural Plaques and Diffuse Pleural Thickening: Three Distinct Benign Responses to Asbestos Exposure. Eur Respir J. 1998;11(5):1021-7. - Pubmed
- 2. Fujimoto N, Kato K, Usami I et al. Asbestos-Related Diffuse Pleural Thickening. Respiration. 2014;88(4):277-84. doi:10.1159/000364948 - Pubmed