Asbestosis

Asbestosis refers to later development of diffuse interstitial fibrosis secondary to asbestos fibre inhalation and should not be confused with other asbestos related diseases.

Asbestosis typically occurs 10-15 years following the commencement of exposure to asbestos and is dose related 3. Heavy asbestos exposure is predominantly encountered among men, as most exposures are occupational in the setting of construction, mining, or ship/automotive industries.

Clinical presentation is insidious and nonspecific with shortness of breath prompting imaging. Alternatively, the presence of asbestosis may become evident when a patient presents with other asbestos related diseases.

Asbestosis is histologically very similar to usual interstitial pneumonia (UIP) with the addition of asbestos bodies 6.

There are no pathognomonic radiological features specific for asbestosis 1. Chest radiograph may show irregular opacities with a fine reticular pattern. Additional evidence of asbestos exposure such as calcified or noncalcified pleural plaques may be evident.

Appearances of asbestosis vary with the duration and severity of the condition. Early manifestations are largely confined to the peripheral region of the lower zones and are subtle. They include:

  • centrilobular dot-like opacities: peribronchial fibrosis
  • intralobular linear opacities: reticulation
  • subpleural lines (often curvilinear)

These changes may be similar in appearance to dependent atelectasis, especially when located posteriorly, and thus supine and prone scans are recommended 3.

As the fibrosis progresses, a number of more definite findings are seen, which continue to be particularly subpleural and lower lung zone in distribution. They include:

Pleural effusions and pleural plaques are common manifestations of asbestos related disease, however hilar and mediastinal lymphadenopathy is usually absent. A careful search for malignancy both of the lung (bronchogenic carcinoma) and pleura (mesothelioma) should be undertaken especially if nodal enlargement is seen.

There is, unfortunately, no proven treatment for asbestosis, and although termination of exposure is, of course, essential, it is usually far too late as many years have invariably already elapsed 5-7.

Cessation of smoking is also mandatory as the two are independent and synergistic risk factors for bronchogenic carcinoma 5.

Progression of disease is variable and appears related to the degree of exposure. Some patients remain stable for many years whereas other progress to end-stage pulmonary fibrosis rapidly 6-7. Causes of death include 7:

Consider other causes of pulmonary fibrosis:

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Article information

rID: 5017
Systems: Chest, Oncology
Section: Pathology
Synonyms or Alternate Spellings:
  • Asbestos related fibrosis

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