Asbestosis typically occurs 10-15 years following the commencement of exposure to asbestos and is dose related 3. Heavy asbestos exposure is predominantly encountered among men, as most exposures are occupational in the setting of construction, mining or ship/automotive industries.
Clinical presentation is insidious and nonspecific with shortness of breath prompting imaging. Alternatively, the presence of asbestosis may become evident when a patient presents with other asbestos related diseases.
There are no pathognomonic radiological features specific for asbestosis 1. Chest radiograph may show irregular opacities with a fine reticular pattern. Additional evidence of asbestos exposure such as calcified or noncalcified pleural plaques may be evident.
Appearances of asbestosis vary with the duration and severity of the condition. Early manifestations are largely confined to the peripheral region of the lower zones and are subtle. They include:
- centrilobular dot-like opacities: peribronchial fibrosis
- intralobular linear opacities: reticulation
- subpleural lines (often curvilinear)
These changes may be similar in appearance to dependent atelectasis, especially when located posteriorly, and thus supine and prone scans are recommended 3.
As the fibrosis progresses, a number of more definite findings are seen, which continue to be particularly subpleural and lower lung zone in distribution. They include:
Pleural effusions and pleural plaques are common manifestations of asbestos related disease, however hilar and mediastinal lymphadenopathy is usually absent. A careful search for malignancy both of the lung (bronchogenic carcinoma) and pleura (mesothelioma) should be undertaken especially if nodal enlargement is seen.
Treatment and prognosis
There is, unfortunately, no proven treatment for asbestosis, and although termination of exposure is, of course, essential, it is usually far too late as many years have invariably already elapsed 5-7.
Cessation of smoking is also mandatory as the two are independent and synergistic risk factors for bronchogenic carcinoma 5.
Progression of disease is variable and appears related to the degree of exposure. Some patients remain stable for many years whereas other progress to end-stage pulmonary fibrosis rapidly 6-7. Causes of death include 7:
- respiratory failure
- cor pulmonale
- asbestos related malignancy, especially
Consider other causes of pulmonary fibrosis:
- in the absence of pleural plaques or diffuse pleural thickening the differentiation may not be possible on imaging alone 4
- presence of centrilobular dot-like or branching opacities, subpleural lines and parenchymal bands may be helpful, as they are more common in asbestosis than in idiopathic pulmonary fibrosis 4
- 1. Chong S, Lee KS, Chung MJ et-al. Pneumoconiosis: comparison of imaging and pathologic findings. Radiographics. 26 (1): 59-77. doi:10.1148/rg.261055070 - Pubmed citation
- 2. Roach HD, Davies GJ, Attanoos R et-al. Asbestos: when the dust settles an imaging review of asbestos-related disease. Radiographics. 2002;22 Spec No : S167-84. Radiographics (link) - Pubmed citation
- 3. Naidich DP, Srichai MB, Krinsky GA. Computed tomography and magnetic resonance of the thorax. Lippincott Williams & Wilkins. (2007) ISBN:0781757657. Read it at Google Books - Find it at Amazon
- 4. Akira M, Yamamoto S, Inoue Y et-al. High-resolution CT of asbestosis and idiopathic pulmonary fibrosis. AJR Am J Roentgenol. 2003;181 (1): 163-9. AJR Am J Roentgenol (full text) - Pubmed citation
- 5. Kilburn KH, Warshaw RH. Severity of pulmonary asbestosis as classified by International Labour Organisation profusion of irregular opacities in 8749 asbestos-exposed American workers. Those who never smoked compared with those who ever smoked. Arch. Intern. Med. 1992;152 (2): 325-7. Arch. Intern. Med. (link) - Pubmed citation
- 6. Stein JH, Eisenberg JM. Internal medicine. Mosby Inc. (1998) ISBN:0815186983. Read it at Google Books - Find it at Amazon
- 7. Thurlbeck WM, Churg A. Thurlbeck's pathology of the lung. Thieme Medical Pub. (2005) ISBN:1588902889. Read it at Google Books - Find it at Amazon
Interstitial lung disease
interstitial lung disease
- drug-induced interstitial lung disease
- hypersensitivity pneumonitis
idiopathic interstitial pneumonia (mnemonic)
- acute interstitial pneumonia (AIP)
- cryptogenic organising pneumonia (COP)
- desquamative interstitial pneumonia (DIP)
- idiopathic nonspecific interstitial pneumonia (NSIP)
- idiopathic pleuroparenchymal fibroelastosis
- lymphoid interstitial pneumonia (LIP)
- respiratory bronchiolitis–associated interstitial lung disease (RB-ILD)
- usual interstitial pneumonia / idiopathic pulmonary fibrosis (UIP/IPF)