Aseptic loosening of hip joint replacements

Aseptic loosening is considered relatively common complication of hip joint replacements. It is usually considered a long-term complication and is often considered as the most common complication 3.

Aseptic loosening can occur as a result of inadequate initial fixation, mechanical loss of fixation over time, or a biological loss of fixation caused by particle-induced osteolysis surrounding the implant.

The causes of particle accumulation vary from implant interface wear, micromotion occurring in response to corrosion, oxidative reactions, and minor pathogen contamination. The initial response to particulate debris can include a subtle inflammatory response, which becomes more pronounced as osteolysis progresses. This inflammatory environment provokes a cellular response which is characterized by elevated levels of secreted factors such as TNF, RANKL, IL-6, IL-1, and IL-11.

A peri-implant lucency of greater than 2 mm or progressive change is considered a concerning feature. Stress views may show an interval change in position. The loosening is not lined by sclerosis. The features may include:

  • medial migration of cement and cup mass
  • change in inclination of the cup

Article information

rID: 30533
Synonyms or Alternate Spellings:
  • Periprosthetic aseptic loosening - hip
  • Aseptic loosening of a hip joint replacement
  • Aseptic loosening of a THR
  • Aseptic loosening of a THR's
  • Aseptic component loosening of hip joint replacements

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Cases and figures

  • Case 1: around proximal femoral stem
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  • Case 2: aseptic loosening of left hip implant
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  • Case 3: aseptic loosening of right hip implant
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