Asherman syndrome

Last revised by Mostafa Elfeky on 31 Oct 2023

Asherman syndrome, also known as uterine synechiae, is a condition characterized by the formation of intrauterine adhesions, which are usually sequela from injury to the endometrium and is often associated with infertility.

There is a tendency for the condition to develop soon after pregnancy (usually within four months 9). The incidence is thought to be increasing probably as a result of increased use of intrauterine interventions.

Patients may present with infertility, pregnancy loss, menstrual abnormalities (e.g. 2ry amenorrhea, hypomenorrhea, dysmenorrhea) or abdominal pain 1.

Intrauterine adhesions result secondary to trauma to the basal layer of the endometrium with subsequent scarring 1. This may be from a previous pregnancy, dilation and curettage, surgery, or infection (e.g. TB endometritis).

The adhesions are composed of fibromuscular-connective tissue bands with or without surrounding superficial epithelial cells or glandular tissue.

Intrauterine adhesions are typically seen on HSG as multiple irregular linear filling defects (may give a lacunar pattern), with the inability to appropriately distend the endometrial cavity 2. In severe cases, there can even be complete non-filling of the uterine cavity.

  • sonohysterography can demonstrate hyperechoic band adhesions across the uterine cavity 10

  • 2D transvaginal ultrasound, suggestive features 11

    • interrupted endometrial line in sagittal plane

    • punctate echogenic foci in the endometrium

    • indistinct endomyometrial junction 

    • indistinct endometrium or thin endometrium (<6 mm) that doesn't increase with hormonal therapy despite normal ovaries and hormonal profile

    • endometrial fluid: commonly loculated appearing as small focal cystic areas within the endometrium

    • hyperechoic lesion without posterior shadowing reflects fibrosis and if with posterior shadowing reflects calcifications

  • 3D transvaginal ultrasound, suggestive features 12

    • irregular endometrial cavity outline in coronal plane

    • decreased endometrial thickness (<2 mm)

    • interrupted endometrial line

    • undetectable endometrium suggests extensive adhesions

    • narrowing of endometrial cavity: transcornual diameter <20 mm and midcavity diameter <10 mm

The adhesions are usually low signal on T2.

The goal of therapy is to remove adhesions and subsequently restore the normal size and shape of the uterine cavity. This is most commonly done by lysis of adhesions via hysteroscopy 3. The reproductive outcome correlates with the type of adhesions and extent of uterine cavity occlusion.

The condition was initially described by Joseph Asherman in 1948 9.

On a hysterosalpingogram consider:

ADVERTISEMENT: Supporters see fewer/no ads