Atypical choroid plexus papilloma
Citation, DOI, disclosures and article data
At the time the article was created Frank Gaillard had no recorded disclosures.
View Frank Gaillard's current disclosuresAt the time the article was last revised Arlene Campos had no financial relationships to ineligible companies to disclose.
View Arlene Campos's current disclosuresAtypical choroid plexus papillomas are WHO grade 2 tumors derived from choroid plexus epithelium with intermediate clinical and pathological features between more indolent choroid plexus papillomas and more aggressive choroid plexus carcinomas.
As clinically, and on imaging, they are difficult to distinguish from choroid plexus papillomas and therefore their description is not repeated here.
Pathology
Atypical choroid plexus papillomas are considered WHO grade 2 tumors in the 2021 WHO classification of CNS tumors 2. They are distinguished from choroid plexus papillomas primarily on the basis of increased mitotic activity (≥2 mitoses per 10 high-power fields; choroid plexus carcinomas have ≥5 mitoses per 10 high-power fields) 1.
Other features that may be present include 1:
increased cellularity
nuclear pleomorphism
more solid growth pattern with blurring of papillary pattern
necrosis
Quiz questions
References
- 1. David N. Louis, Hiroko Ohgaki, Otmar D. Wiestler et al. WHO Classification of Tumours of the Central Nervous System. (2016) ISBN: 9789283244929 - Google Books
- 2. Louis D, Perry A, Wesseling P et al. The 2021 WHO Classification of Tumors of the Central Nervous System: A Summary. Neuro-Oncology. 2021;23(8):1231-51. doi:10.1093/neuonc/noab106 - Pubmed
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