Balloon breast brachytherapy
Citation, DOI, disclosures and article data
At the time the article was created Stefano Pacifici had no recorded disclosures.View Stefano Pacifici's current disclosures
Balloon breast brachytherapy (BBB) is a technique for delivering radiation treatment in women with early-stage breast cancer. It is given after lumpectomy, or surgical removal of a small breast neoplasm, and is a shorter alternative to the more traditional method of external beam radiation for seven weeks.
Balloon breast brachytherapy is performed with the Mammosite® device, a single soft catheter with a balloon at the tip, placed in the lumpectomy cavity, either at the time of lumpectomy or as an office procedure following surgery. The balloon is then inflated with saline solution up to a diameter of about 2 inches to accommodate the individual cavity, after which a 192Ir radiation source, connected to a computer-controlled high-dose-rate remote afterloader, is inserted into the inflated balloon and left in situ for several minutes to deliver the radiation dose.
The treatments, which takes about 20 minutes each, are usually given in outpatient fashion twice daily for five days. Once the therapy is concluded, the balloon is deflated and the catheter is removed. This method is similar to that used for prostate cancer brachytherapy, using radioactive seeds, and is completely painless.
- a substantial decrease in the duration of therapy (five days compared to seven weeks for external beam radiation)
- reduction of the amount of healthy tissue exposed to radiation
- excellent cosmetic outcome
- inadequate skin distance
- poor cavity conformance
- 1. Ravi A, Lee S, Karsif K et-al. MammoSite multilumen catheter: dosimetry considerations. J Cancer Res Ther. 7 (1): 64-8. doi:10.4103/0973-1482.80469 - Pubmed citation
- 2. Beitsch PD, Shaitelman SF, Vicini FA. Accelerated partial breast irradiation. J Surg Oncol. 2011;103 (4): 362-8. doi:10.1002/jso.21785 - Pubmed citation
- 3. Dickler A. Technology insight: MammoSite--a new device for delivering brachytherapy following breast-conserving therapy. Nat Clin Pract Oncol. 2007;4 (3): 190-6. doi:10.1038/ncponc0739 - Pubmed citation
- 4. Benitez PR, Streeter O, Vicini F et-al. Preliminary results and evaluation of MammoSite balloon brachytherapy for partial breast irradiation for pure ductal carcinoma in situ: a phase II clinical study. Am. J. Surg. 2006;192 (4): 427-33. doi:10.1016/j.amjsurg.2006.06.013 - Pubmed citation
- 5. Benitez PR, Streeter O, Vicini F et-al. Preliminary results and evaluation of MammoSite balloon brachytherapy for partial breast irradiation for pure ductal carcinoma in situ: a phase II clinical study. Am. J. Surg. 2006;192 (4): 427-33. doi:10.1016/j.amjsurg.2006.06.013 - Pubmed citation
- 6. Cuttino LW, Vicini FA. Early outcomes data for accelerated partial breast irradiation using balloon brachytherapy. Expert Rev Anticancer Ther. 2011;11 (9): 1351-5. doi:10.1586/era.11.113 - Pubmed citation
- 7. Segala JJ, Cardarelli GA, Hiatt JR et-al. Interface dosimetry for electronic brachytherapy intracavitary breast balloon applicators. J Appl Clin Med Phys. 2011;12 (2): 3221. - Pubmed citation