Citation, DOI & article data
BALT lymphoma is an abbreviated term for bronchus-associated lymphoid tissue lymphoma. These neoplasms fall under the broader umbrella of mucosa associated lymphoid tissue (MALT) lymphomas. It is sometimes considered a type of primary pulmonary lymphoma.
Up to half of patients can be asymptomatic and tumors are often discovered incidentally.
BALT lymphoma represents a low-grade B-lymphocyte lymphoma composed of monotonous small lymphocytes with focal plasmacytoid features. They are composed of subepithelial lymphoid follicles distributed along distal bronchi and bronchioles.
The tumors can have a number of associations which include 1:
- Sjögren syndrome
- amyloid deposition
- collagen vascular disease
- Helicobacter pylori infection
Appearances can be quite variable. Described features include:
- solitary, well-delineated soft-tissue masses - most BALT lymphoma cases
- less common imaging features include
- hilar and mediastinal lymphadenopathy: not a prominent radiologic finding with nodal involvement present at pathologic analysis in 30% of cases 3
Treatment and prognosis
Most tend to be slow-growing lesions. The disease is often localized at the time of diagnosis and responds favourably to treatment.
- 1. Bae YA, Lee KS, Han J et-al. Marginal zone B-cell lymphoma of bronchus-associated lymphoid tissue: imaging findings in 21 patients. Chest. 2008;133 (2): 433-40. doi:10.1378/chest.07-1956 - Pubmed citation
- 2. Hayashi D, Devenney-cakir B, Lee JC et-al. Mucosa-associated lymphoid tissue lymphoma: multimodality imaging and histopathologic correlation. AJR Am J Roentgenol. 2010;195 (2): W105-17. doi:10.2214/AJR.09.4105 - Pubmed citation
- 3. Giménez A, Franquet T, Prats R et-al. Unusual primary lung tumors: a radiologic-pathologic overview. Radiographics. 22 (3): 601-19. Radiographics (full text) - Pubmed citation
- 4. Tamura A, Komatsu H, Yanai N et-al. Primary pulmonary lymphoma: relationship between clinical features and pathologic findings in 24 cases. The Japan National Chest Hospital Study Group for Lung Cancer. Jpn. J. Clin. Oncol. 1995;25 (4): 140-52. Jpn. J. Clin. Oncol. (link) - Pubmed citation
- 5. Lee IJ, Kim SH, Koo SH et-al. Bronchus-associated lymphoid tissue (BALT) lymphoma of the lung showing mosaic pattern of inhomogeneous attenuation on thin-section CT: a case report. Korean J Radiol. 1 (3): 159-61. Korean J Radiol (link) - Free text at pubmed - Pubmed citation
- 6. Lee DK, Im JG, Lee KS et-al. B-cell lymphoma of bronchus-associated lymphoid tissue (BALT): CT features in 10 patients. J Comput Assist Tomogr. 24 (1): 30-4. J Comput Assist Tomogr (link) - Pubmed citation