Barium sulfate contrast medium
Citation, DOI, disclosures and article data
At the time the article was created Daniel J Bell had no recorded disclosures.View Daniel J Bell's current disclosures
At the time the article was last revised Andrew Murphy had no financial relationships to ineligible companies to disclose.View Andrew Murphy's current disclosures
Barium sulfate (BaSO4), often just called barium in radiology parlance, is an ionic salt of barium (Ba), a metallic chemical element with atomic number 56. Barium sulfate forms the basis for a range of contrast media used in fluoroscopic examinations of the gastrointestinal tract. Unlike barium and many of its other salts, barium sulfate is insoluble in water and therefore very little of the toxic barium metal is absorbed into the body.
On this page:
It is the preferential contrast agent for gastrointestinal (GI) fluoroscopic examinations 2 due to:
high attenuation of x-rays
lack of absorption from the gut into the body
lack of toxicity (in the gut)
It can also be found in some oral contrast preparations used for CT.
Barium can be mixed into high-density or low-density suspensions. Both suspensions typically attenuate x-rays more than water-soluble contrast. High-density barium is preferred over water-soluble contrast for fine-detail evaluation of the gastrointestinal system (e.g. evaluation for early changes from Crohn disease). Suspensions created for CT use are very low density.
Due to its insolubility in water, barium sulfate contrast media are supplied as fine particles of the barium sulfate suspended in water. Often artificial flavourings are added to make the mixture more palatable.
Its allergy profile is favorable with very few reported reactions 1. Historically, allergy was more common when excipients, such as chocolate, were used 1.
known or strongly suspected gastrointestinal perforation
may be used in evaluation for possible esophageal perforations, see below
large volume aspiration risk
prior allergic reaction (rare)
left-sided colonic obstruction (relative contraindication)
if the barium cannot exit the colon, it has the potential to become inspissated and very hard, leading to a quite problematic constipation
Barium contrast agents may cause a peritonitis if they leak into the peritoneal space. If bowel perforation is suspected, water-soluble contrast is generally preferred 3.
The evidence that barium causes a pleuritis and/or mediastinitis if it leaks into the pleural space and/or mediastinum respectively is weak. The initial work establishing a relationship between barium and pleuritis was performed in cats and the analogy extended to humans on theoretical grounds 4. However more recent research suggests that these concerns are unfounded and no case reports of clinically-significant barium-induced pleural/mediastinal inflammation exist. When looking for an esophageal tear, barium is safe to use after ruling out a large leak with water soluble-contrast 5.
Barium contrast is not directly toxic to the airways (unlike hyperosmolar water-soluble contrast (e.g. Gastrografin)), and in the past it has even been used to create bronchograms 6. Barium does, however, have the potential to plug the distal airways, diminishing the capacity for gas exchange, and barium aspiration may rarely be fatal 8.
Barium migration into the bloodstream, known as intravasation is a serious and rare complication, with the potential to cause fatal end-organ emboli - especially pulmonary, although it is incredibly rare if the contrast is used appropriately 7.
- 1. Gelfand DW, Sowers JC, DePonte KA, Sumner TE, Ott DJ. Anaphylactic and allergic reactions during double-contrast studies: is glucagon or barium suspension the allergen?. AJR. American journal of roentgenology. 144 (2): 405-6. doi:10.2214/ajr.144.2.405 - Pubmed
- 2. Beckett KR, Moriarity AK, Langer JM. Safe Use of Contrast Media: What the Radiologist Needs to Know. Radiographics : a review publication of the Radiological Society of North America, Inc. 35 (6): 1738-50. doi:10.1148/rg.2015150033 - Pubmed
- 3. Yamamura M, Nishi M, Furubayashi H, Hioki K, Yamamoto M. Barium peritonitis. Report of a case and review of the literature. Diseases of the colon and rectum. 28 (5): 347-52. Pubmed
- 4. James AE, Montali RJ, Chaffee V, Strecker EP, Vessal K. Barium or gastrografin: which contrast media for diagnosis of esophageal tears?. Gastroenterology. 68 (5 Pt 1): 1103-13. Pubmed
- 5. Gollub MJ, Bains MS. Barium sulfate: a new (old) contrast agent for diagnosis of postoperative esophageal leaks. Radiology. 202 (2): 360-2. doi:10.1148/radiology.202.2.9015057 - Pubmed
- 6. TEIXEIRA J, TEIXEIRA LC. Bronchography without oil and iodine; the use of barium as a contrast medium. Diseases of the chest. 36: 256-64. Pubmed
- 7. Fowlie S, Barton JR, Fraser GM. Barium embolisation during barium enema examination: a report of a case and a review of the literature. (1987) The British journal of radiology. 60 (712): 404-6. doi:10.1259/0007-1285-60-712-404 - Pubmed
- 8. Yan GW, Deng JF, Bhetuwal A, Yang GQ, Fu QS, Chen H, Hu N, Zeng H, Fan XP, Yan GW, Wu XL. A case report and literature review of barium sulphate aspiration during upper gastrointestinal examination. (2017) Medicine. 96 (47): e8821. doi:10.1097/MD.0000000000008821 - Pubmed