Barrett esophagus

Last revised by Henry Knipe on 15 Jun 2023

Barrett esophagus is a term for intestinal metaplasia of the esophagus. It is considered the precursor lesion for esophageal adenocarcinoma.

Barrett esophagus is thought to have a prevalence of 3-15% in patients with reflux esophagitis. Mean age at diagnosis is 55 years old 5.

Known risk factors for Barrett esophagus include 10:

Barrett esophagus is asymptomatic and usually discovered in a workup for GERD.

Barrett esophagus represents progressive metaplasia of esophageal stratified squamous cell epithelium to columnar epithelium. Although the exact number varies, 90-100% of esophageal adenocarcinoma is thought to arise from this metaplasia.

Although patients with Barrett esophagus have a 30x risk of developing esophageal adenocarcinoma 2, the annual risk of developing adenocarcinoma depends on the degree of histological dysplasia, but may be ~1% (range 0.1-2%), and the absolute risk is low 3.

Because Barrett esophagus represents metaplasia, it is often occult on imaging. Early esophageal adenocarcinoma arising out of Barrett esophagus also may be difficult to see. No radiological imaging modalities are adequate for screening.

  • double-contrast esophagogram 7

    • signs of reflux esophagitis 

      • reflux

      • long stricture in the mid or lower esophagus

      • large deep solitary ulcer

      • fine reticular mucosal pattern

      • thickened irregular mucosal folds 

    • earliest signs of developing adenocarcinoma: localized flattening, stiffening, or irregularity in the wall of a stricture

There is a ~70% chance of Barrett esophagus in a midthoracic esophageal stricture ref.

Since Barrett esophagus is considered a premalignant lesion, confirmation with upper endoscopy and biopsy is warranted.

If Barrett esophagus is confirmed on biopsy, then aggressive therapy for gastro-esophageal reflux is pursued, and perhaps endoscopic surveillance, depending on the patient's age and other risk factors.

One surveillance and biopsy protocol suggests 4:

  • low-grade dysplasia: 6-12 months

  • high-grade dysplasia: 3 months

If there is mucosal irregularity (what would be seen on an esophagogram), then endoscopic resection has been recommended 4. Prophylactic resection or ablation has been used by some, particularly in younger patients.

Barrett esophagus is named after Norman Rupert Barrett (1903-1979) 11, an Australian-born thoracic surgeon, who first described the condition in 1950 9.

ADVERTISEMENT: Supporters see fewer/no ads