Benign regressive post-infectious neurological disorders

Benign regressive post-infectious neurological disorders (BRPINDs) refer to a group of neurological disorders and must be differentiated from the more malignant and progressive post-infectious neurological disorders such as SSPE (subacute sclerosing panencephalomyelitis) or rubella panencephalitis.

Benign regressive postinfectious neurological disorders (BRPIND) include:

That have the following main characteristics:

  • these disorders are commonly postinfectious of postvaccination in origin (developing within 5 days to 3-5 weeks after infection or vaccination
  • they are inflammatory demyelinative white matter diseases in nature characterised pathologically by autoimmune demyelination, breakdown of blood brain barrier with the development of vasogenic oedema and contrast enhancement in the acute stage
  • the MRI signal changes (mainly MRI T2 hyperintensities) observed in these disorders are mainly due to the development of vasogenic oedema
  • they commonly have an acute onset and a regressive course
  • they commonly have a benign course with good prognosis and full functional recovery should be expected in most cases
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Article Information

rID: 15232
Tags: refs, cases
Synonyms or Alternate Spellings:
  • Benign regressive post infectious neurological disorders (BRPINDS)

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