Bethesda criteria of hereditary non-polyposis colorectal cancer
The Bethesda criteria are an alternative to the Amsterdam criteria for the clinical diagnosis of hereditary non-polyposis colorectal cancer (HNPCC).
Diagnosis of HNPCC is made if any of the following criteria are fulfilled:
- Amsterdam criteria are met
- 2 or more HNPCC related malignancies
- patient with colorectal cancer (CRC) has
- first-degree relative with CRC or HNPCC related cancer; one of the cancers diagnosed <45 years of age, and the adenoma diagnosed <40 years of age
- CRC and endometrial cancer <45 years of age
- right-sided undifferentiated (solid or cribriform) CRC on histology diagnosed <45 years of age
- signet ring type CRC <45 years of age
- colonic adenomas <40 years of age
- 1. Chapman Anthony Hugh and Jean François Adell. Radiology and imaging of the colon. Springer, 2004. ISBN: 3540435972, 9783540435976.