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- a longitudinal vaginal septum may be present in ~25% of cases
- as with other Mullerian duct anomalies, abnormalities of the renal tract may also be present
In most cases, a bicornuate uterus is incidentally discovered when the pelvis is imaged. The most common symptomatic presentation is with early pregnancy loss and cervical incompetence 6. Infertility is not usually a problem with this type of malformation because implantation of the embryo is not impaired.
A bicornuate uterus is divided according to the involvement of the cervical canal:
- bicornuate bicollis: two cervical canals; central myometrium extends to the external cervical os
- bicornuate unicollis: one cervical canal; central myometrium extends to the internal cervical os
The preferred methods of imaging uterine anomalies are ultrasound, hysterosalpingogram or MRI. The external uterine contour is concave or heart-shaped, and the uterine horns are widely divergent. The fundal cleft is typically more than 1 cm deep and the intercornual distance is widened.
The uterus is seen as comprising caudally fused symmetric uterine cavities with some degree of communication between the two cavities (usually at the uterine isthmus). Although not a specific finding, the angle between the horns of the bicornuate uterus is usually more than 105° 3.
A divided uterus can be seen, but it is difficult to differentiate between septate and bicornuate anomalies since the uterine fundal contour is not visible 5. Accuracy of hysterosalpingogram alone is only 55% in differentiation between both entities. An angle of less than 75° between the uterine horns is suggestive of a septate uterus while an angle of more than 105° is more consistent with a bicornuate uterus.
May help confirm anatomy by showing a deep (>1 cm) fundal cleft in the outer uterine contour and an intercornual distance of >4 cm. The uterus demonstrates normal uterine zonal anatomy.
Treatment and prognosis
Surgical intervention is usually not indicated in the absence of reproductive difficulties.
In women with a history of recurrent pregnancy loss and in whom no other infertility issues have been identified a Strassman metroplasty can be considered.
In patients with cervical incompetence, placement of a cervical cerclage may increase fetal survival rates 9. Indeed, the association between cervical incompetence and a bicornuate uterus is so high, that prophylactic cerclage may be appropriate in some instances.
- uterus didelphys: complete failure of fusion occurs during the development of the paramesonephric ducts with duplication of the uterus, cervix and vagina
- septate uterus: has a normal fundal contour but is characterized by a persistent longitudinal septum that partially divides the uterine cavity 12
Septate uterus increases the risk of early pregnancy loss, and hysteroscopic intervention to resect the septum is sometimes pursued. In this situation, differentiation between a septate uterus or a bicornuate uterus is critical. This is mostly a problem with HSG preoperative evaluation. Attempted resection of a bicornuate uterus "septum" leads to a poor outcome.
- 1. Dähnert W. Radiology review manual. Lippincott Williams & Wilkins. (2003) ISBN:0781738954. Read it at Google Books - Find it at Amazon
- 2. Reuter KL, Babagbemi TK. Obstetric and gynecologic ultrasound. Mosby Inc. (2006) ISBN:0323039766. Read it at Google Books - Find it at Amazon
- 3. Ly JQ. Rare bicornuate uterus with fibroid tumors: hysterosalpingography-MR imaging correlation. AJR Am J Roentgenol. 2002;179 (2): 537-8. AJR Am J Roentgenol (full text) - Pubmed citation
- 4. Mueller GC, Hussain HK, Smith YR et-al. Müllerian duct anomalies: comparison of MRI diagnosis and clinical diagnosis. AJR Am J Roentgenol. 2007;189 (6): 1294-302. doi:10.2214/AJR.07.2494 - Pubmed citation
- 5. Steinkeler JA, Woodfield CA, Lazarus E et-al. Female infertility: a systematic approach to radiologic imaging and diagnosis. Radiographics. 29 (5): 1353-70. doi:10.1148/rg.295095047 - Pubmed citation
- 6. Troiano RN, Mccarthy SM. Mullerian duct anomalies: imaging and clinical issues. Radiology. 2004;233 (1): 19-34. doi:10.1148/radiol.2331020777 - Pubmed citation
- 7. Dykes, Thomas M.; Siegel, Cary; Dodson, William. Imaging of Congenital Uterine Anomalies: Review and Self-Assessment Module American Journal of Roentgenology. 189 (3_Supplement): S1. doi:10.2214/AJR.06.0821
- 8. Mintz MC, Thickman DI, Gussman D et-al. MR evaluation of uterine anomalies. AJR Am J Roentgenol. 1987;148 (2): 287-90. AJR Am J Roentgenol (abstract) - Pubmed citation
- 9. Nahum GG. Uterine anomalies. How common are they, and what is their distribution among subtypes? J Reprod Med. 1998;43 (10): 877-87. - Pubmed citation
- 10. Chan YY, Jayaprakasan K, Zamora J et-al. The prevalence of congenital uterine anomalies in unselected and high-risk populations: a systematic review. Human Reproduction Update. 2011;doi:10.1093/humupd/dmr028 - Pubmed citation
- 11. Imaoka I, Wada A, Matsuo M et-al. MR imaging of disorders associated with female infertility: use in diagnosis, treatment, and management. Radiographics. 23 (6): 1401-21. doi:10.1148/rg.236025115 - Pubmed citation
- 12. Chaudhry S. AJR Teaching File: infertility in a young woman. AJR Am J Roentgenol. 2007;189 (3): S11-2. doi:10.2214/AJR.07.7019 - Pubmed citation
- 13. Abo Dewan K, Hefeda M, ElKholy D. Septate or Bicornuate Uterus: Accuracy of Three-Dimensional Trans-Vaginal Ultrasonography and Pelvic Magnetic Resonance Imaging. The Egyptian Journal of Radiology and Nuclear Medicine. 2014;45(3):987-95. doi:10.1016/j.ejrnm.2014.04.001
- 14. Zakarin Safier L & Rackow B. Bicornuate Uterus. Congenital Müllerian Anomalies. 2016;:95-104. doi:10.1007/978-3-319-27231-3_8