Biotin (less commonly known as vitamin B7) is a water-soluble vitamin, part of the vitamin B complex, and a coenzyme for many reactions, including gluconeogenesis and the synthesis of fatty acids and amino acids.
Biotin deficiency is very rare.
Biotin excess does not seem to produce any ill-effects 3. However large doses of biotin in those on vitamin supplements may interfere with biochemical assays leading to misdiagnoses e.g. hyperthyroidism 4.
Recent work suggests that biotin may have a role in the treatment of secondary progressive multiple sclerosis 5.
Interestingly, it was formerly known as vitamin H or coenzyme R.
- 1. Pamela C. Champe, Richard A. Harvey (Ph. D.), Denise R. Ferrier. Biochemistry. ISBN: 0781769604
- 2. Zempleni, J., Hassan, Y. I., & Wijeratne, S. S. (2008). Biotin and biotinidase deficiency. Expert Review of Endocrinology & Metabolism, 3(6), 715–724. http://doi.org/10.1586/174466126.96.36.1995
- 3. Chawla J, Kvarnberg D. Hydrosoluble vitamins. (2014) Handbook of clinical neurology. 120: 891-914. doi:10.1016/B978-0-7020-4087-0.00059-0 - Pubmed
- 4. Piketty ML, Polak M, Flechtner I, Gonzales-Briceño L, Souberbielle JC. False biochemical diagnosis of hyperthyroidism in streptavidin-biotin-based immunoassays: the problem of biotin intake and related interferences. (2017) Clinical chemistry and laboratory medicine. 55 (6): 780-788. doi:10.1515/cclm-2016-0606 - Pubmed
- 5. Mock DM. Biotin: From Nutrition to Therapeutics. (2017) The Journal of nutrition. 147 (8): 1487-1492. doi:10.3945/jn.116.238956 - Pubmed
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