Bladder inflammatory pseudotumor

Dr Ayush Goel and Radswiki et al.

Bladder inflammatory pseudotumor is a non-neoplastic proliferation of cells.

This entity is more common in adults, with a mean age at diagnosis of 38 years. 

Patients present most commonly with an ulcerating bleeding mass, hematuria, and voiding symptoms.

Although not neoplastic, the lesions can be locally aggressive and may mimic malignancy clinically, at cystoscopy, and at imaging. 

As such, it is critical that the pathologist distinguishes inflammatory pseudotumor from rhabdomyosarcoma and myxoid leiomyosarcoma to prevent unnecessary radical surgery.

The pathogenesis of inflammatory pseudotumor remains unclear.

Inflammatory pseudotumors usually appear as a solitary bladder mass, which may be exophytic or polypoid. Ulceration may also be evident. 

On CT and MR images, inflammatory pseudotumors demonstrate enhancement.

Enhancement may be ring-like secondary to the cellular periphery with a necrotic center.

Treatment may consist of surgery, a regimen of high-dose steroids, radiation therapy, or conservative management.

Article information

rID: 12699
System: Urogenital
Tag: cases, refs
Synonyms or Alternate Spellings:

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