Bladder inflammatory pseudotumour

A bladder inflammatory pseudotumour is a nonneoplastic proliferation of cells.

This entity is more common in adults, with a mean age at diagnosis of 38 years. 

Patients present most commonly with an ulcerating bleeding mass, haematuria, and voiding symptoms.

Although not neoplastic, the lesions can be locally aggressive and may mimic malignancy clinically, at cystoscopy, and at imaging. 

As such, it is critical that the pathologist distinguishes inflammatory pseudotumour from rhabdomyosarcoma and myxoid leiomyosarcoma to prevent unnecessary radical surgery.

The pathogenesis of inflammatory pseudotumour remains unclear.

Inflammatory pseudotumours usually appear as a solitary bladder mass, which may be exophytic or polypoid. Ulceration may also be evident. 

On CT and MR images, inflammatory pseudotumours demonstrate enhancement.

Enhancement may be ring-like secondary to cellular periphery with a necrotic centre.

Treatment may consist of surgery, a regimen of high-dose steroids, radiation therapy, or conservative management.

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Article information

rID: 12699
System: Urogenital
Synonyms or Alternate Spellings:

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