Bland thrombus is a term used to describe any non-malignant venous thrombus (e.g. a "normal" DVT). However the term is most often used in the context of malignancy, to differentiate non-malignant clot from the malignant form, as management of the two may differ; of course they often coexist.
In the patient with malignancy, bland thrombus may form due to abnormalities of Virchow's triad, e.g. venous flow hemodynamic changes secondary to extrinsic compression of a nearby tumor not by direct invasion, usually at the portal vein and IVC in a setting of hepatic, renal or other proximate malignancy. The correct discrimination from tumor thrombus is helpful for therapeutic strategies and prognostication.
It appears on cross-sectional imaging as a non-enhancing luminal filling defect with no definite continuity with the adjacent tumor tissue. It may be adherent to an intact vein wall with no luminal expansion (although acute bland thrombus may mildly expand the vessel).
Acute thrombosis may be difficult to detect with grey-scale imaging alone, as the thrombus may be anechoic/hypoechoic. With time, it becomes more echogenic and easier to identify.
Color Doppler should be able to demonstrate partial or complete flow defect in the affected vein. It can also help to differentiate it from tumor thrombus, which will show internal color vascularity. Bland thrombus, in comparison, is avascular on color Doppler 1.
It appears as a hypodense intraluminal structure with no enhancement after contrast. Contrast is necessary to differentiate it from the nearby tumor and delineating it from the surrounding adjacent luminal flow. On unenhanced CT, bland thrombus shows lower density values (mean 33 HU) cf. tumor thrombus (mean 81 HU) 2.
Acute thrombus appears of high signal intensity on T1 and T2 weighted sequences. Chronic thrombus appears of low T2 signal or appears as a flow voids. In both situations, it shows no enhancement or diffusion restriction 3.
Bland thrombus generally shows non-restricted diffusion. It shows higher ADC values than tumor thrombus 4. Yet, it may demonstrate low ADC values due to the high viscosity as well as paramagnetic effects of intracellular deoxyhemoglobin and methemoglobin contents 5.
Beware of slow or turbulent flow artefacts.
Treatment and prognosis
Bland thrombus may resolve after thrombolytic and anticoagulant therapy, unlike tumor thrombus.
- 1. Chuanming Li, Jiani Hu, Daiquan Zhou, Jun Zhao, Kuansheng Ma, Xuntao Yin, Jian Wang. Differentiation of bland from neoplastic thrombus of the portal vein in patients with hepatocellular carcinoma: application of susceptibility-weighted MR imaging. (2014) BMC Cancer. 14 (1): 590. doi:10.1186/1471-2407-14-590 - Pubmed
- 2. Canellas R, Mehrkhani F, Patino M, Kambadakone A, Sahani D. Characterization of Portal Vein Thrombosis (Neoplastic Versus Bland) on CT Images Using Software-Based Texture Analysis and Thrombus Density (Hounsfield Units). (2016) AJR. American journal of roentgenology. 207 (5): W81-W87. doi:10.2214/AJR.15.15928 - Pubmed
- 3. Catalano OA, Choy G, Zhu A, Hahn PF, Sahani DV. Differentiation of malignant thrombus from bland thrombus of the portal vein in patients with hepatocellular carcinoma: application of diffusion-weighted MR imaging. (2010) Radiology. 254 (1): 154-62. doi:10.1148/radiol.09090304 - Pubmed
- 4. Catalano OA, Choy G, Zhu A, Hahn PF, Sahani DV. Differentiation of malignant thrombus from bland thrombus of the portal vein in patients with hepatocellular carcinoma: application of diffusion-weighted MR imaging. (2010) Radiology. 254 (1): 154-62. doi:10.1148/radiol.09090304 - Pubmed
- 5. Quencer KB, Friedman T, Sheth R, Oklu R. Tumor thrombus: incidence, imaging, prognosis and treatment. (2017) Cardiovascular diagnosis and therapy. 7 (Suppl 3): S165-S177. doi:10.21037/cdt.2017.09.16 - Pubmed