Blue rubber bleb naevus syndrome

Blue rubber bleb nevus syndrome (BRBNS) or Bean syndrome, is a rare sporadic syndrome characterised by multifocal venous anomalies. Patients often have multiple soft blue skin lesions associated with multiple bowel venous malformations, which could lead to lower gastrointestinal bleeding

The skin and gastrointestinal tract are the primary sites of Involvement it can affect multiple other organ systems which include musculoskeletal system, vulva, submandibular region, parotid region, thymus, masticator space, cranium (sinus pericranii). Involvement of the orbits, thyroid, heart, pericardium, lungs, peritoneal cavity, adrenal glands, and kidneys have also been rarely reported 3.

The association of “haemangiomas” of the skin and gastrointestinal tract was first reported in 1860 by Gascoyen. It was fully characterised by William Bean in 1958 2.

Vascular tumours and malformations
Share article

Article Information

rID: 44141
System: Vascular
Section: Syndromes
Synonyms or Alternate Spellings:
  • Bean syndrome
  • Bean's syndrome
  • Blue rubber bleb nevus syndrome
  • Blue rubber bleb nevus syndrome (BRBNS)

Support Radiopaedia and see fewer ads

Updating… Please wait.

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.