Bone marrow edema
Citation, DOI & article data
Bone marrow edema is the term given to abnormal fluid signal seen within the bone marrow on MRI. It is a non-specific, yet important imaging finding, usually indicating the presence of underlying pathology.
There is a long (long) list of possible causes of this finding:
- primary: bone marrow edema syndrome (no cause found)
- trauma: fractures, bone contusion, ligamentous injury, etc.
- arthropathy: e.g. degenerative joint disease, rheumatoid arthritis, etc.
- hypoperfusion: e.g. sickle cell disease
- infective: e.g. osteomyelitis, diskitis, septic arthritis
- iatrogenic: e.g. chemotherapy, postoperative, chronic corticosteroid therapy
- neurological: neuropathic arthropathy
- neoplastic: malignancies e.g. bone metastases, and benign e.g. giant cell tumor, chondroblastoma, osteoid osteoma
- miscellaneous: e.g. chronic renal failure
Dual-energy CT may demonstrate bone marrow edema using fluid-sensitive "edema maps", however its sensitivity and specificity is poorer than that of MRI 5.
Bone marrow edema is generally primarily identified on MRI and is best investigated using fat-suppressed T2W sequences.
There will be intermediate T1 signal, with high T2 signal in the fat of the bone marrow (usually fat-suppressed sequences required to see the increased T2 signal).
However other imaging modalities may then have a role in investigating the underlying cause.
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