Botryoid rhabdomyosarcoma

A botryoid rhabdomyosarcoma is a type of embryonal rhabdomyosarcoma and accounts for 5-10% of all rhabdomyosarcomas 6

It tends to occur in paediatric population, often between birth and 15 years of age 7.

Rhabdomyosarcomas generally have a nonspecific infiltrative appearance, the botryoid variant is unusual in that it manifests as a polypoid or "grape-like lesion" beneath the mucosa. It does not infiltrate the epithelium, and is described to have an intratubular appearance5.

Distribution

They occur principally beneath a mucous membrane 3,6. Recognised sites of occurrence include:

With vaginal and urinary bladder locations being the most common.

MRI

Lesions can be large. Signal characteristics are similar to rhabdomyosarcoma i.e 1:

  • T1: low to intermediate
  • T2: high

Grapelike intraluminal masses would favour a botryoides type.

Macroscopic differential diagnoses for the vaginal and urinary bladder locations based on the polypoid appearance include 5:

  • yolk sac tumour
  • tumoral cystits

For the pelvic/presacral region consider:

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Article information

rID: 7851
Section: Pathology
Tag: cases
Synonyms or Alternate Spellings:
  • Botryoides rhabdomyosarcoma
  • Sarcoma botryoides

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