A botryoid rhabdomyosarcoma is a type of embryonal rhabdomyosarcoma and accounts for 5-10% of all rhabdomyosarcomas 6.
It tends to occur in paediatric population, often between birth and 15 years of age 7.
Rhabdomyosarcomas generally have a nonspecific infiltrative appearance, the botryoid variant is unusual in that it manifests as a polypoid or "grape-like lesion" beneath the mucosa. It does not infiltrate the epithelium, and is described to have an intratubular appearance5.
They occur principally beneath a mucous membrane 3,6. Recognised sites of occurrence include:
- vagina 6
- urinary bladder 6
- cervix 2
- biliary tract - rhabdomyosarcoma of biliary tracts 4
With vaginal and urinary bladder locations being the most common.
Lesions can be large. Signal characteristics are similar to rhabdomyosarcoma i.e 1:
- T1: low to intermediate
- T2: high
Grapelike intraluminal masses would favour a botryoides type.
Macroscopic differential diagnoses for the vaginal and urinary bladder locations based on the polypoid appearance include 5:
- yolk sac tumour
- tumoral cystits
For the pelvic/presacral region consider:
- 1. Wong-you-cheong JJ, Woodward PJ, Manning MA et-al. From the Archives of the AFIP: neoplasms of the urinary bladder: radiologic-pathologic correlation. Radiographics. 26 (2): 553-80. doi:10.1148/rg.262055172 - Pubmed citation
- 2. Houghton JP, Mccluggage WG. Embryonal rhabdomyosarcoma of the cervix with focal pleomorphic areas. J. Clin. Pathol. 2007;60 (1): 88-9. doi:10.1136/jcp.2005.034769 - Free text at pubmed - Pubmed citation
- 3. Foxx SD, Smoker WR, Ghatak NR et-al. Primary rhabdomyosarcoma of the scalp. AJNR Am J Neuroradiol. 1995;16 (7): 1511-3. AJNR Am J Neuroradiol (citation) - Pubmed citation
- 4. Donnelly LF, Bisset GS, Frush DP. Diagnosis please. Case 2: Embryonal rhabdomyosarcoma of the biliary tree. Radiology. 1998;208 (3): 621-3. Radiology (citation) - Pubmed citation
- 5. Agrons GA, Wagner BJ, Lonergan GJ et-al. From the archives of the AFIP. Genitourinary rhabdomyosarcoma in children: radiologic-pathologic correlation. Radiographics. 17 (4): 919-37. Radiographics (abstract) - Pubmed citation
- 6. Schepper A.M. De, F. Vanhoenacker, P.M. Parizel and J. Gielen. Imaging of Soft Tissue Tumors. 3rd ed. Springer, 2005. ISBN: 3540248099.
- 7. Kransdorf Mark J and Mark D Murphey. Imaging of Soft Tissue Tumors. Second Edition. Lippincott Williams & Wilkins, 2006. ISBN: 0781747716.