Botryoid rhabdomyosarcoma

Last revised by Francis Deng on 20 Jan 2020

Botryoid rhabdomyosarcoma, also known as sarcoma botryoides, is a type of embryonal rhabdomyosarcoma and accounts for 5-10% of all rhabdomyosarcomas 6

It tends to occur in pediatric population, often between birth and 15 years of age 7.

Rhabdomyosarcomas generally have a nonspecific infiltrative appearance, the botryoid variant is unusual in that it manifests as a polypoid or "grape-like lesion" beneath the mucosa. It does not infiltrate the epithelium, and is described to have an intratubular appearance5.

They occur principally beneath a mucous membrane 3,6. Recognized sites of occurrence include:

With vaginal and urinary bladder locations being the most common.

Lesions can be large. Signal characteristics are similar to rhabdomyosarcoma i.e 1:

  • T1: low to intermediate
  • T2: high

Grapelike intraluminal masses would favor a botryoides type.

Botryoid, derived from the Greek bótry(s) for grape, means resembling the form of grapes.

Macroscopic differential diagnoses for the vaginal and urinary bladder locations based on the polypoid appearance include 5:

  • yolk sac tumor
  • tumoral cystits

For the pelvic/presacral region consider:

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